Changes in the kidneys can lead to increased blood pressure, which can be followed by an increase in cortisol levels. Subtotal nephrectomy is one of the methods to provide animal models of hypertension. The combination of kefir milk and jicama as a synbiotic drink is expected to maintain cortisol under normal levels in hypertensive conditions. Aim: This study aims to determine the effect of kefir and jicama synbiotic beverage on rats' serum cortisol levels after a subtotal nephrectomy procedure. Methods: Male Wistar rats were divided into five groups, i.e. a group of subtotal nephrectomy, sham group, and three synbiotic groups receiving subtotal nephrectomy procedure and synbiotics with differences in composition (Syn 1, Syn 2, and Syn 3). The serum cortisol levels were measured with ELISA after a month of kefir and jicama synbiotic administration. The results were analyzed statistically using one-way ANOVA. Results: The serum cortisol levels (ng/mL) were 165.49
Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Serum C-Reactive Protein (CRP) is an important marker that is significantly significant in the severity of COVID-19 patient outcomes. An increase in CRP indicates an increased risk of disease progression. IL-6 levels will also increase to become a strong predictor of the risk of damage to the respiratory system. This study aims to determine the relationship between CRP of COVID-19 patients with severity and outcome. This study is an observational study with a cross-sectional design. The subjects involved in the study were COVID-19 patients at the dr. Soedono Madiun in the period January 2020 - April 2021. The instrument used is secondary data in medical records from RSUD dr. Soedono Madiun. There was no significant difference in CRP levels in 114 patients hospitalized for <12 days and >12 days (p=0.051), then the duration of hospitalization was also not correlated with CRP levels (p=0.70, r =-0.251). In addition, there was a significant difference in CRP levels between patients with severe and non-severe severity (p=0.0013). The patient’s severity was also positively correlated with CRP level (p=0.012, r=0.233). There was a significant difference in CRP levels in patients with recovered and dead outcomes and was positively correlated (p=0.000, r=0.378). CRP levels are related to the severity and outcome of COVID-19 patients. A high CRP indicates severity and risk of death.International Journal of Human and Health Sciences Vol. 06 No. 04 Oct’22 Page: 452-456
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