Co-crystals of 4-hydroxybenzoic acid and 2,3,5,6-tetramethylpyrazine (2 : 1) exhibit the first supramolecular synthon polymorphism in a co-crystal; metastable anti-hierarchic polymorph I converts to stable hierarchic form II.

Herein, we report transition metal-catalyzed intramolecular cyclization of o-(1-alkynyl)benzenesulfonamides to afford 3-substituted benzothiazines regioselectively via a C-N bond forming reaction and Cu-catalyzed sequential C-N and C-C bond formation leading to the corresponding 3,4-disubstituted derivatives.

The title compound {systematic name: [2-(1-hydroxycyclohexyl)-2-(4-hydroxyphenyl)ethyl]dimethylammonium 3-carboxypropanoate monohydrate}, C(16)H(26)NO(2)(+) x C(4)H(5)O(4)(-) x H(2)O, is a succinate salt of O-desmethylvenlafaxine (desvenlafaxine). The present structure is one of four reported polymorphs of this salt, which is a new antidepressant drug. The carboxyl group of the succinate anion adopts a rare anti conformation and is engaged in a very short O-H...O(-) hydrogen-bond contact. Both cations and anions are involved separately in the formation of distinct O-H...O hydrogen-bonded networks. Desvenlafaxine cations and water molecules self-assemble to generate a honeycomb layer, while the succinate anions form a linear tape structure. These hydrogen-bonded networks are interlinked via N-H...O and O-H...O hydrogen bonds. The hydrogen-bonding network is so strong that desolvation and melting occur together at approximately 402 K. Thus, the crystal structure may be used to understand the thermal stability and solubility of the compound at the molecular level.

A new one-pot reaction for the regioselective construction of a six-membered fused N-heterocyclic ring leading to isoquinolones under Pd/C-Cu catalysis is described.

Some physical properties of palmyrah fruit were investigated in this study. The average values of major, medium, minor and geometric mean diameters of fresh whole palmyrah fruit were 11.54,10.45, 9.85 and 10.64 cm respectively at 47.34 % (w.b) moisture content whereas that of palmyrah nut were 8.59, 7.35, 4.99 and 6.79 cm respectively at 8% (w.b) moisture content. Sphericity, surface area and aspect ratio were found to be 91.94%, 359.17 cm2 and 0.90 for fruit and whereas that of nut were 79.19%, 145.16 cm2 and 0.86 respectively. The average mass of the individual palmyrah fruit and nut was 927.78 and 248.10 g whereas bulk density was 525.92 and 693.0 kg/m3 respectively. The coefficient of static friction on mild steel, glass and plywood surfaces were 0.27, 0.21 and 0.25 for palmyrah fruit and 0.36, 0.28 and 0.27 for nut respectively. The angle of repose of palmyrah fruit and nut were 30.77 and 44.03 respectively.