Context: Congenital bleeding disorders are abnormalities of hemostasis that may present with significant difficulties in diagnosis and management.Aims: This study was done to know various clinical presentations of congenital bleeding disorders and also to note the hematological changes associated with them.
Materials and methods:This was a hospital based study conducted at haematology unit, Department of Pathology, JJM Medical College, Davangere. The present study includes 110 cases referred to our department with history of bleeding disease were evaluated clinically and investigated appropriately to detect the underlying cause for the abnormal hemostatic function.Results: This clinico-hematological study of congenital bleeding disorders showed Glanzmann's thrombasthenia in 4 cases (3.64%). The remaining 106 cases are had diseases affecting clotting factor which included Hemophilia A -70 cases; Hemophilia B -19 cases; Factor VII deficiency -1 case; afibrinogenemia -1 case; Factor XIII deficiency -3 cases; vWD -11 cases and dysfibrinogenemia -1 case. Vascular disorders were not encountered. Majority of these cases presented with hemarthrosis and muscle hematoma. Plasma clotting tests (APTT) were prolonged in majority of cases, corrected with aged serum, adsorbed plasma, F VIII deficient plasma, F IX deficient plasma. Factor assay showed mild, moderate and severe forms.
Conclusion:In spite of various advanced diagnostic investigations, the basic hematological investigation remains first panel or step towards the approach to the diagnosis of congenital bleeding disorders.
Abnormal uterine bleeding(AUB) is one of the most common gynaecological problems, which accounts for about 33% of out patient referrals. It is a debilitating condition with high direct and indirect costs. AUB is considered as a cause of significant health care burden for women, their families and society as a whole. To study the various histomorphological patterns of endometrium in AUB. This is a retrospective study done in Department of Pathology, tertiary care hospital, JJMMC Davangere for a period of 2 years from January 2016 to December 2017. 212 cases of endometrial biopsies were reviewed in AUB. The slides were obtained from departmental archives and clinical data from the histopathological forms. The data was entered and interpreted in Microsoft Excel and the analysis was done in percentages and proportions and was represented in tables, graphs and pie charts wherever necessary. A total of 212 cases were analysed and the age of females ranged from 20-62 yrs. The most common histomorphological pattern was Endometrial Hyperplasia without atypia in 43.0% of cases followed by Secretory endometrium in 15.6% of cases. Proliferative endometrium was seen in 14.6% of cases and Disordered proliferative endometrium was seen in 14.2% of cases. There were also 2 cases with Simple atypical hyperplasia. The cause of AUB can be identified by the histopathological study of endometrial curettages and biopsies. This helps to plan for successful management of the females presenting with AUB.
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