Scandium radionuclides / Sc-47 radiobioconjugates / Radionuclide therapy Summary. Radionuclides with medium energy beta emission and a several day half-life are attractive candidates for radioimmunotherapy. Among the most promising in this category is 47 Sc produced by fast neutron irradiation (E n > 1 MeV) of titanium target with high energy neutrons in 47 Ti(n, p) 47 Sc nuclear reaction. In the previously reported production scheme the dissolution of the TiO 2 target in hot concentrated H 2 SO 4 and evaporation of the resulting solution were the most timeconsuming steps. The present paper describes new, simple and efficient production method of 47 Sc, where the slow dissolution of the target is avoided. After irradiation in fast neutron flux 47 TiO 2 and Li 2 47 TiF 6 targets were dissolved in HF solutions. Next 47 Sc was separated from the target using anion exchange resin Dowex 1 with 0.4 M HF + 0.06 M HNO 3 solution as eluent. The eluted 47 Sc was adsorbed on cation exchange resin and eluted with 0.5 M of ammonium acetate. The 47 Sc separation yield in the proposed procedure is about 90% with the separation time less than 2 h. The obtained nocarrier-added 47 Sc was used to label DOTATATE conjugate with 96% labeling yield.
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