This paper will discuss the design and construction of BESIII [1], which is designed to study physics in the τ-charm energy region utilizing the new high luminosity BEPCII double ring e + ecollider [2]. The expected performance will be given based on Monte Carlo simulations and results of cosmic ray and beam tests. In BESIII, tracking and momentum measurements for charged particles are made by a cylindrical multilayer drift chamber in a 1 T superconducting solenoid. Charged particles are identified with a time-of-flight system based on plastic scintillators in conjunction with dE/dx (energy loss per unit pathlength) measurements in the drift chamber. Energies of electromagnetic showers are measured by a CsI(Tl) crystal calorimeter located inside the solenoid magnet. Muons are identified by arrays of resistive plate chambers in the steel magnetic flux return. The level 1 trigger system, Data Acquisition system and the event filter system based on networked computers will also be described.

Fatty acid photodecarboxylase (FAP) is a photoenzyme with potential green chemistry applications. By combining static, time-resolved, and cryotrapping spectroscopy and crystallography as well as computation, we characterized Chlorella variabilis FAP reaction intermediates on time scales from subpicoseconds to milliseconds. High-resolution crystal structures from synchrotron and free electron laser x-ray sources highlighted an unusual bent shape of the oxidized flavin chromophore. We demonstrate that decarboxylation occurs directly upon reduction of the excited flavin by the fatty acid substrate. Along with flavin reoxidation by the alkyl radical intermediate, a major fraction of the cleaved carbon dioxide unexpectedly transformed in 100 nanoseconds, most likely into bicarbonate. This reaction is orders of magnitude faster than in solution. Two strictly conserved residues, R451 and C432, are essential for substrate stabilization and functional charge transfer.