Purpose Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is associated with transplant-related toxicities, which may have a profound impact on a patient's physical functioning and body composition. In order to analyze the effect of exercise therapy on muscle mass and physical functioning in patients receiving allo-HSCT, we measured muscle mass and physical functioning before and after allo-HSCT.
Adult T-cell leukemia-lymphoma (ATL) is one of the most malignant lymphomas with poor prognosis. ATL cells express CC chemokine receptor 4 (CCR4) and mogamulizumab, a monoclonal antibody against CCR4 that exhibits very strong cytotoxicity for ATL cells via antibody-dependent cellular cytotoxicity. Although its effect is dramatic in ATL, serious adverse reactions such as Stevens-Johnson syndrome have been reported. However, these eruptions can appear as therapeutic signs of mogamulizumab. We evaluated the effectiveness of mogamulizumab in five acute-type ATL patients. Peripheral blood (PB) and lymph nodes (LN) were affected in three and four patients, respectively. In PB, complete response (CR) was obtained in all three patients and partial response (PR) was recorded in LN of one patient. In skin lesions, four of five patients manifested CR; in two, the lesions worsened after the start of mogamulizumab treatment and subsequently improved. In these lesions, CD4 developed in two patients with CR; they did not show a relapse of ATL over the course of 9 months. Our findings suggest that mogamulizumab should be continued and surface marker evaluation should be performed even in patients whose skin lesions show aggravation, and that CAR may be a marker for a favorable prognosis.
Many computer-security defenses are reactive-they operate only when security incidents take place, or immediately thereafter. Recent efforts have attempted to predict security incidents before they occur, to enable defenders to proactively protect their devices and networks. These efforts have primarily focused on long-term predictions. We propose a system that enables proactive defenses at the level of a single browsing session. By observing user behavior, it can predict whether they will be exposed to malicious content on the web seconds before the moment of exposure, thus opening a window of opportunity for proactive defenses. We evaluate our system using three months' worth of HTTP traffic generated by 20,645 users of a large cellular provider in 2017 and show that it can be helpful, even when only very low false positive rates are acceptable, and despite the difficulty of making "on-the-fly" predictions. We also engage directly with the users through surveys asking them demographic and security-related questions, to evaluate the utility of self-reported data for predicting exposure to malicious content. We find that self-reported data can help forecast exposure risk over long periods of time. However, even on the long-term, self-reported data is not as crucial as behavioral measurements to accurately predict exposure.
CCS CONCEPTS• Security and privacy → Network security; Human and societal aspects of security and privacy; • Computing methodologies → Neural networks; KEYWORDS Exposure prediction; network security; proactive security ACM Reference Format:
This paper proposes a Scalable Internet Bandwidth Reservation Architecture (SIBRA) as a new approach against DDoS attacks, which, until now, continue to be a menace on today's Internet. SIBRA provides scalable inter-domain resource allocations and botnet-size independence, an important property to realize why previous defense approaches are insufficient. Botnetsize independence enables two end hosts to set up communication regardless of the size of distributed botnets in any Autonomous System in the Internet. SIBRA thus ends the arms race between DDoS attackers and defenders. Furthermore, SIBRA is based on purely stateless operations for reservation renewal, flow monitoring, and policing, resulting in highly efficient router operation, which is demonstrated with a full implementation. Finally, SIBRA supports Dynamic Interdomain Leased Lines (DILLs), offering new business opportunities for ISPs.
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