Between 1972 and 1996, 450 consecutive patients with intracranial meningiomas were operated on at Cukurova University School of Medicine. By size, intracranial meningiomas were classified as huge (>6 cm minimum diameter when extrapolated to anatomic size) or not huge (<6 cm). The present study involves 93 patients who underwent 109 craniotomies for the removal of huge meningiomas. All patients are adult, with 31 men and 62 women or a 1:2 male to female ratio, with a mean age of 48.7 +/- 2.3 years at the time of diagnosis. The average duration of observed survival in 85 patients followed in the computed tomography (CT) era was 4.8 years and that of 8 patients in the pre-CT era was 8.8 years. Eleven patients died by the last follow-up assessment. Seventy-nine patients were still alive at the last follow-up assessment. The overall postoperative mortality rate was 3.2%. The overall recurrence rate was 19%. In descending order of frequency, the first five anatomic locations of the huge meningiomas were the parasagittal region in 18 patients (19.3%), the cerebral convexity in 15 (16.1%), the olfactory groove in 15 (16.1%), the falx in 12 (12.9%), and the tuberculum sellae in 11 (11.8%). The overall results of surgical treatment in 93 patients were total removal in 59 (63.4%), radical subtotal in 18 (18.3%), and subtotal in 16 (17.2%), with good outcome in 69 (74.1%), fair in 16 (17.2%), and poor in 5 (5.3%). In conclusion, the huge size of meningiomas affects the extent of removal, recurrence rate, postoperative outcome, operative morbidity and mortality rates, and survival time negatively.

Objective: This study aims to investigate the role of IGF-1 in the development of nodular thyroid disease. Material and Methods:A total number of 100 consecutive patients operated for nodular thyroid disease in our institution were included in this prospective study. In addition to classical pathological examinations, nodules and extranodular healthy tissues were sampled and immunochemically stained for IGF-1. The materials were independently evaluated using an Allred Scoring System ranging from 0 to 8. If the score was ≥1, the tissue was accepted as IGF-1 positive.Results: IGF-1 positivity was observed in 88% and 58% of the samples obtained from nodules and extranodular healthy tissues, respectively. Allred 8-unit scores were higher in benign nodules (n=89; 4.1±2.3) and papillary carcinomas (n=7; 6.7±1.3), than in extranodular healthy tissues in the same patients (2.3±2.3 and 3.3±1.9, respectively); and higher in papillary carcinomas than in benign nodules, when the scores were compared to each other (p<0.01 for all comparisons).Conclusions: Allred 8-unit scores for IGF-1 increase in the presence of benign thyroid nodules, papillary cancer. The results of our study support the findings of previous studies demonstrating the role of IGF-1 in the development of thyroidal nodules.

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ÖzAmaç: Çalışmamızın amacı, bir üniversite hastanesine başvuran geriatrik hastaların popülasyonunu ve kök kanal tedavilerinin insidansını değerlendirmektir.Gereç ve yöntem: Ocak, Şubat ve Mart 2019'da Marmara Üniversitesi Diş Hekimliği Fakültesi'ne başvuran hasta sayısı elde edilmiştir. Bu hastalar arasından 65 yaş ve üzeri olan hastalar belirlenmiştir. Hastalar cinsiyete ve yaşa göre temelde iki gruba ayrılmıştır. Daha sonra bu hastalar içerisinden 65 yaş üstü 50 hasta rastgele seçilmiştir. Yaş kategorisinde genç yaşlılar (65-74), yaşlılar (75-84), çok yaşlılar (85 ve üstü) bulunmaktadır. Her hastanın panoramik röntgenleri tek bir araştırmacı tarafından incelenmiş ve kök kanal tedavileri tespit edilmiştir.Bulgular: Toplam 2762 hasta yeni giriş yapmıştır. Bu hastalar içerisinde 185 birey geriatrik hastadır. Gruplar; 65-69, 70-74, 75-79 yaş arası hastalardan oluşmaktadır. 65-69 yaş arası 100 bireyin 36'sını kadın, 64'ünü erkek hastalar oluşturmaktadır. 70-74 yaş arası 61 bireyin 26'sı kadın 35'i erkektir. 75-79 yaş arası 19 hastanın ise 9'u kadın 10'u erkektir. Fakülteye son 3 ayda 80 yaş ve üzeri sadece 5 hasta girişi olduğu görülmüştür. Rastgele seçilen 50 geriatrik hasta içerisinde ise 65 yaşından büyük 50 hastadan 22'si erkek, 28'i kadındı. 65-74 yaş grubuna ait birey sayısı 39, 75-84 yaş grubuna ait birey sayısı 9, 85 yaş ve üzeri birey sayısı ise 2'dir. Gruplarda kanal tedavisi görmüş hastaların sayısı sırasıyla 18, 5 ve 1'dir. Sonuç:Hastaların yaşı arttıkça kök kanal tedavilerinin sayısı azalmaktadır. Bu durumun sebebinin, toplumumuzda artan yaşla birlikte ağızdaki diş sayısının azalması olabileceğini düşünmekteyiz. AbstractAim: The aim of our study was to assess the number of root canal treatments amongst geriatric patients admitted to a university hospital.Materials and methods: The number of patients admitted to Marmara University Faculty of Dentistry in January, February and March 2019 was obtained. Among these patients, patients aged 65 years and over were identified. Patients were basically divided into two groups according to gender and age. Age categories were 65-69, 70-74 and 75-79.Then fifty patients over the age of 65 were selected randomized. The patients were subdivided into two categories; according to gender and age. The age category included young olds (65-74), old olds (75-84), oldest olds (85 and over). The panoramic x-rays of each patient were examined by a single operator and root canal treatments were detected.Results: A total of 2762 patients have just admitted. Among these patients, 185 were geriatric. Groups; It consists of patients between the ages of 65-69, 70-74, 75-79. Of the 100 patients aged 65-69 years, 36 were female and 64 were male. Of the 61 patients aged 70-74, 26 were female and 35 were male. Of the 19 patients aged 75-79, 9 were female and 10 were male. In the last 3 months, only 5 patients aged 80 and over were admitted to the faculty.Amongst 50 selected patients who were over the age of 65, 22 were male and 28 were female. The number of young olds were 39, old olds we...

The differential diagnosis of facial granulomas can be challenging in some cases, as multiple diseases have similar histopathological findings. Herein we describe a 36-year-old male with granulomatous rosacea that was initially diagnosed as papulonecrotic tuberculid based on the initial histopathological sections analyzed. This case presentation aimed to highlight both the need for re-evaluation of clinical findings and that examination of new histopathologic sections may be necessary for a definitive diagnosis of facial granulomas.