Fluoxetine hydrochloride (FH) in combination with Olanzapine (OZ) is used in treatment of depressive episodes associated with bipolar disorder. The first derivative spectrophotometric method for simultaneous determination of fluoxetine hydrochloride (FH) and olanzapine (OZ) from two component tablet dosage form has been developed and validated. Chromatographic methods viz. HPLC and HPTLC methods were reported in the literature for the simultaneous determination of FH and OZ from combined dosage forms. In the present investigation an attempt has been made to develop accurate, reproducible, rapid and cost-effective method for simultaneous determination of FH and OZ in pharmaceutical formulation. The wavelengths selected for determination of FH and OZ is 235.5nm and 296nm, respectively. The beer's law was obeyed in the concentration range of 8-80μg/mL and 2-20μg/mL for Fluoxetine and Olanzapine, respectively. The proposed methods were validated and successfully applied to the determination of FH and OZ in tablet formulations. The results suggested that the proposed procedures can be used for routine quality control of tablets containing FH and OZ.
Substituted anilines were reacted with ethyl-2-bromopropionate to give different substituted 2-bromo-N-phenylpropionamides, which were further condensed with o-phenylenediamines to give corresponding 3-methyl-N-phenyl-3,4-dihydroquinoxalin-2-amines. 4-ethyl-3-methyl-N-phenyl-3,4-dihydroquinoxalin-2-amines were synthesized by the N-alkylation of 3-methyl-N-phenyl-3,4
2-bromo-N-phenylpropionamides;
-dihydroquinoxalin-2-amines using ethyl iodide.
A new spectrophotometric method was developed for simultaneous determination of compounds with interfering spectra in binary mixtures without previous separation, showing significant advantages over the conventional methods regarding minimal data manipulation and applicability. The proposed method was applied for the determination of Propranolol hydrochloride and Hydrochlorothiazide in Tablets formulation, for determination of sampling wavelength, 10 μg/ml of each of PRO and HCT were scanned in 200-400 nm range and sampling wavelengths were 289 nm for PRO and 270 nm for HCT are selected for development and validation of simultaneous equation method. For this method linearity observed in the range of 10-50 μg/ml for PRP and 5-25 μg/ml for HCT, and in their pharmaceutical formulation with mean percentage recoveries100.13± 0.86 and 100.07± 0.58, respectively. The method was validated according to ICH guidelines and can be applied for routine quality control testing.
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