Back ground: World is now moving towards the natural therapies due to many reasons not the topic of discussion. Majority of the available allopathic drugs are derived from the natural primary sources either from the animals or plants. Garlic and its derivative have been tested for many illnesses like hyperlipidemia, anti-platelet aggregation and HTN the current study focused on exploring the mechanism of glucose lowering properties of the S-allylcysteine, a garlic derivative.Methodology: Rats were randomly divided into 3 groups with 10 rats in each group A was +ve control with no intervention, group B was kept -ve control given alloxon to induce hyperglycemia only, group C was given alloxon and S-allylcysteine . Blood sample were drawn after 7, 14 and 21 days to assess glucose random levels and plasma insulin concentrations. SPSS version22 using ANOVA as statistical technique was applied for data analysis.Results: There was a significant reduction in blood glucose levels from 300+81.3mg/dl 364 +43.16and 218.+36.38mg/dl in S-allylcysteine treated group at 7, 14 and 21 days respectively with p-value 0.0001. Similarly serum insulin levels were also improved from3.87+2.16, 8.0+1.6and 11.5 +1.69U/Lin s-allyl cysteine group p-value 0.000021. Conclusion:Alloxon induced hypo-insulinemia was successfully corrected by S-allyl cysteine fitting it into insulin secretogogue category.
Introduction Aplastic anemia is a rare and potentially life-threatening hematological disorder with incidence of 1.4 to 14 cases/million. It is associated with exposures to certain environmental chemicals, drugs and infections. The objective was to investigate the association of illness with family history of aplastic anemia, exposure to pesticides and chemicals. Methodology A hospital-based case–control study (191 cases, 696 controls) was conducted from 1st January 2015 to 31st December 2018 in Karachi, Sindh. Cases were patients with diagnosis of aplastic anemia confirmed with bone marrow biopsy. Controls neither had aplastic anemia nor other hematological chronic diseases. An in-person interview was conducted to collect demographic information, family history of aplastic anemia, and history of pesticide and chemical exposure. The adjusted odds ratios (aOR) with 95% confidence intervals (CI) were estimated via SPSS v22. Results A total of 191 confirmed aplastic anemia cases were selected. Mean age was 29 years (range: 4–69) and predominantly there were males 129 (67.5%). The majority, 84 (44.0%), of the cases were aged 16–30 years. In multivariate analysis models, the significant associations were observed between aplastic anemia with family history of aplastic anemia (aOR=13.3, 95% C.I 3.66–48.50), exposure to pesticides (aOR=2.1, 95% C.I 1.23–3.61) and chemicals (aOR=3.6, 95% C.I 2.06–6.34). Conclusion This study observed a significant association of aplastic anemia with family history of aplastic anemia, exposure to pesticide and insecticide exposure. However, to establish this connection, further longitudinal studies are warranted.
Background: Aplastic anemia although a rare hematological disorder but it is associated with poor prognosis and high mortality. It is a matter of greater public health concern for the Asian population with prevalence 3 times greater than other part of the globe. Exposures of specific drugs, chemicals and others have been connected with an AA etiology. We aimed to examine the association of antimicrobial drugs exposures with AA. Methods: We conducted a case-control study in Karachi, Pakistan, selecting the patients with two blood lineages depressed on bone marrow biopsy as the cases while patients without any hematological disorder as controls. For each case four age-sex matched control were enrolled. Information associated to socio-demographics and exposure to antibiotics was collected on a questionnaire during personal interview. Results: We identified 191 cases with an age range of 1-66 years and 696 controls. Predominant participants were male (67%), female being 33%. Antimicrobial drugs were used by 49.74% of aplastic anemia cases whereas the use was reported in 29.31% controls. Beta-lactam antibiotics, chloramphenicol, macrolides, Trimethoprim/Sulfamethoxazole, tetracycline and others were the drug categories evaluated. Conclusion: Antimicrobials were reported to be used more frequently in aplastic anemia cases as compared to their normal controls
Objectives: To determine the various patterns of headache presenting to Neurology OPD Liaquat University Hospital Jamshoro/Hyderabad. Study Design: Descriptive, cross-sectional study. Setting: Department of Neurology, Liaquat University of Medical & Health Sciences (LUMHS). Period: July to December 2016. Methods: Data was collected on developed profoma, the same was analyzed on SPSS 22nd version. Results: Out of 238 patients, 61 (25.6%) were male 177 (74.4%) were female patients. Age group distribution of study population ranged from 04 - 65 years with mean age was 31.66 with standard deviation of12.72. Out of 238 patients 170 (71.4%) were diagnosed as primary headache disorders, 56 (17%) were secondary headache while 12 (%) were labeled as cranial neuropathies and facial pains. Migraine without aura 113(65.3%) followed by tension type headache 35(20.2%) were most common primary headache disorder. Among secondary headaches Cervicogenic headache 16(30.2%) was most common cause followed by headache secondary to sinusitis, hypertension and trauma 8(15.1%), 7 (13.2%) and 6(11.3%) respectively. Trigeminal Neuralgia 9 (75.0%) was most common painful cranial neuropathies. Conclusion: Primary as well as secondary headache disorders are most prevalent in female at an age range of 21-40 years with majority of them suffering from migraine followed by tension and Cervical origin respectively.
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