Microfluidics-based biochips consist of microfluidic arrays on rigid substrates through which, movement of fluids is tightly controlled to facilitate biological reactions. Biochips are soon expected to revolutionize biosensing, clinical diagnostics, and drug discovery. Critical to the deployment of biochips in such diverse areas is the dependability of these systems. Thus, robust testing techniques are required to ensure an adequate level of system dependability. Due to the underlying mixed technology and energy domains, such biochips exhibit unique failure mechanisms and defects. In this article we present a highly effective fault diagnosis strategy that uses a single source and sink to detect and locate multiple faults in a microfluidic array, without flooding the array, a problem that has hampered realistic implementations of all existing strategies. The strategy renders itself well for a built-in self-test that could drastically reduce the operating cost of microfluidic biochips. It can be used during both the manufacturing phase of the biochip, as well as field operation. Furthermore, the algorithm can pinpoint the actual fault, as opposed to merely the faulty regions that are typically identified by strategies proposed in the literature. Also, analytical results suggest that it is an effective strategy that can be used to design highly dependable biochip systems.
Mez is a novel publish-subscribe messaging system for latency sensitive multi-camera machine vision applications at the IoT Edge. The unlicensed wireless communication in IoT Edge systems are characterized by large latency variations due to intermittent channel interference. To achieve user specified latency in the presence of wireless channel interference, Mez takes advantage of the ability of machine vision applications to temporarily tolerate lower quality video frames if overall application accuracy is not too adversely affected. Control knobs that involve lossy image transformation techniques that modify the frame size, and thereby the video frame transfer latency, are identified. Mez implements a network latency feedback controller that adapts to channel conditions by dynamically adjusting the video frame quality using the image transformation control knobs, so as to simultaneously satisfy latency and application accuracy requirements. Additionally, Mez uses an application domain specific design of the storage layer to provide low latency operations. Experimental evaluation on an IoT Edge testbed with a pedestrian detection machine vision application indicates that Mez is able to tolerate latency variations of up to 10x with a worst-case reduction of 4.2% of the application accuracy F1 score metric. The performance of Mez is also experimentally evaluated against state-of-the-art low latency NATS messaging system.
Microfluidics-based biochips consist of microfluidic arrays on rigid substrates through which movement of fluids is tightly controlled to facilitate biological reactions. Biochips are soon expected to revolutionize biosensing, clinical diagnostics, environmental monitoring, and drug discovery. Critical to the deployment of the biochips in such diverse areas is the dependability of these systems. Thus robust testing and diagnosis techniques are required to ensure adequate level of system dependability. Due to the underlying mixed technology and mixed energy domains, such biochips exhibit unique failure mechanisms and defects. In this article efficient parallel testing and diagnosis algorithms are presented that can detect and locate single as well as multiple faults in a microfluidic array without flooding the array, a problem that has hampered realistic implementation of several existing strategies. The fault diagnosis algorithms are well suited for built-in self-test that could drastically reduce the operating cost of microfluidic biochip. Also, the proposed alogirthms can be used both for testing and fault diagnosis during field operation as well as increasing yield during the manufacturing phase of the biochip. Furthermore, these algorithms can be applied to both online and offline testing and diagnosis. Analytical results suggest that these strategies that can be used to design highly dependable biochip systems.
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