Les brûlures de l’enfant peuvent être à l’origine de troubles ioniques graves, entrainant une morbi-mortalité importante. Ce travail avait pour objectif de décrire les perturbations de l’ionogramme sanguin chez les enfants brûlés, afin de contribuer à l’amélioration des soins. Il s’est agi d’une étude transversale rétrospective allant du 01 janvier 2017 au 30 juin 2019. Ont été inclus les enfants hospitalisés dans le service de chirurgie du CHU pédiatrique Charles de Gaulle pour brûlure et chez lesquels un ionogramme sanguin a été réalisé. L’étude a porté sur 212 enfants, avec un âge moyen de 38,52 mois et un sex ratio de 1,12. La surface corporelle brûlée moyenne était de 26,60% et le délai moyen d’admission de 5,71 heures. La mortalité était de 16,98%. L’ionogramme sanguin à l’entrée a retrouvé une hyponatrémie (27,88%), une hypobicarbonatémie (53,95%), une hypoprotidémie (26,67%) et une hyperchlorémie (53,59%). Au contrôle, ces troubles ioniques étaient toujours présents. S’y sont associées une hypocalcémie (30,43%), une hypomagnésémie (27,27%) et une hyperphosphatémie (28,79%). La natrémie, la bicarbonatémie et la protidémie à l’entrée étaient significativement plus basses chez les patients décédés. Les brûlures de l’enfant sont fréquentes. Leur évolution est marquée par des perturbations de l’ionogramme sanguin et une mortalité élevée.Mots clés : Brûlure, Ionogramme sanguin, Enfants, Burkina Faso. English title: Blood ionogram profile in burned children at the Charles de Gaulle University Pediatric Hospital of Ouagadougou (Burkina Faso)Burns in children can be the cause of serious ionic disorders, leading to significant morbidity and mortality. The aim of this study was to describe the disturbances in the blood ionogram of burnt children, in order to contribute to the improvement of care. This was a retrospective cross-sectional study from 01 January 2017 to 30 June 2019. Children hospitalised in the surgery department of the Charles de Gaulle Pediatric University Hospital for burns and in whom a blood ionogram was carried out were included. Our study involved 212 children, with an average age of 38.52 months and a sex ratio of 1.12. The average body surface area burned was 26.60% and the average admission time was 5.71 hours. Mortality was 16.98%. The blood ionogram at the entrance showed hyponatremia (27.88%), hypobicarbonatremia (53.95%), hypoprotidemia (26.67%) and hyperchloremia (53.59%). At the control, these ionic disorders were still present. They were associated with hypocalcaemia (30.43%), hypomagnesemia (27.27%) and hyperphosphatemia (28.79%). Natremia, bicarbonateemia and protidemia were significantly lower on admission in patients who died in the course of the evolution. Childhood burns are frequent at the CHUP-CDG; their evolution is marked by disturbances of the blood ionogram and high mortality.Keywords: Burns, Blood Ionogram, Children, Burkina Faso.
Breast cancer is the leading cause of cancer death in women worldwide. The aim of this study was to determine the value of post-therapy serum LDH in assessing response at the completion of chemotherapy in breast cancer patients. This was a prospective cross-sectional study with data collection from May 2019 to November 2020, at the University Hospital of Bogodogo and at the SANDOF Polyclinic. We performed the LDH assay on serum from patients at the end of breast cancer chemotherapy who were at least 18 years old. Thirty (30) patients were included, with a mean age of 47.47 ± 2.10 years. Based on RECIST criteria, 46.67% had a successful response to chemotherapy, while 53.33% had a poor response. The mean post-therapy serum LDH was 256.15±25.99 U/L and 46.67% of patients had elevated serum LDH. Mean serum LDH was significantly higher in patients with a personal history of breast cancer (p=0.0198), increased CA 15-3 (p=0.0489) and poor response to chemotherapy (p=0.0291). Serum LDH was significantly higher in patients with a poor response to chemotherapy. Further studies are required to establish a more reliable correlation between serum LDH levels and response to breast cancer chemotherapy.
Introduction:The main objective of this study was to investigate abnormalities of serum protein fractions in hemodialysis patients with chronic renal failure (CRF) in Ouagadougou, Burkina Faso. Methods: This was a descriptive cross-sectional study of 48 hemodialysis patients with chronic renal failure (CRF) recruited at the Yalgado Ouedraogo Teaching Hospital (YO-TH), and 48 controls declared fit to donate blood by the Regional Blood Transfusion Center (RBTC) of Ouagadougou. Urea, creatinine, uric acid, and serum proteins were measured on the ARCHITECT C4000 equipment (ABOTT ® ), while the separating of the different protein fractions was performed on the Helena SAS 3 & 4 automated system. Results: A total of 96 individuals were included in the study. Protein levels were on average higher in controls (75.19 ± 6.56 g/L) than in hemodialysis patients (71.44 ± 12.33 g/L). Low blood albumin was significantly associated with the CRF hemodialysis groups compared to controls (p < 0.000). In terms of globin fractions, a significant increase in alpha-globulin 1, alpha-globulin 2 and gamma-globulin was present in the CRF hemodialysis group compared to controls (p < 0.000); while beta-globulin was on average lower in the CRF hemodialysis group compared to controls without significant difference (p = 0.509). Analysis of the electrophoretic profiles identified 57.17% polyclonal hypergammaglobulinaemia, 33.33% inflammatory profile, 10.42% undernutrition profile and 2.08% nephrotic syndrome in the CRF hemodialysis group. Conclusion: Serum protein electrophoresis is rapidly feasible and low cost. In hemodialysis CKD patients, it can be used to guide therapeutic management and predict morbidity and mortality related to variations in the various protein fractions.
Introduction: The aim of this study was to investigate ionic disorders in malaria and dengue co-infection at Ouagadougou, Burkina Faso. Material and methods: This is a descriptive cross-sectional study with retrospective data collection, carried out in the laboratory of the Pediatric University Hospital Charles de Gaulle in Ouagadougou, Burkina Faso, from January 1st, 2017 to December 31st, 2019. The study was on patients who performed a thick blood drop/smear, dengue serology and blood ionogram. Results: On 1405 cases included in the study, 102 patients (7.26%) were confirmed of malaria. Dengue serology was positive in 235 patients (16.72%). The frequency of co-infection was 1.14% (n=16). The mean age of the patients was 9.93 years and the age group of 0 to 15 years represented 78.93% of the cases. There was a male predominance with a sex ratio (M/F) of 2.58. Hyponatremia (40%), hypercalcemia (40%), hypokalemia (30%) and hypophosphatemia (30%) were the main blood ionogram disturbances in malaria and dengue co-infection. The statistically significant disturbances in case of malaria and dengue co-infection were the absence of hypobicarbonatemia (p=0.036). Conclusion: Malaria and dengue are responsible for significant morbidity and mortality in Burkina Faso. Although co-infection was rare in the study (1.14%), it was associated with several blood ionogram disturbances. Evaluation and consideration of these disturbances during treatment would contribute to a better care of patients.
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