The concept of phage therapy exists in the history and it has been ignored for a long time, but the consequence of drug resistance in pathogen bacteria has forced the forgotten kingdom of phage therapy to be re-explored. However, for the successful implementation and acceptance of phage therapy worldwide, the number of factors need to be addressed. In pharmacology of phage therapy, pharmacodynamics is a straightforward concept, on the other hand, owing to the unique feature of phages to replicate and their high sensitivity, pharmacokinetics is rather complex. In this review, we have discussed pharmacokinetics and some recent advances in delivery systems as to achieve the therapeutically effective concentrations of phage in their activated form.
Background: Infl uenza generally known as fl u is due to viruses that contaminate the respiratory region. It can result in light to cruel sickness, and may cause death. The infl uenza pandemic of 1918-1919 took life of a lot more people than the World War 1. Peramivir that inhibits the purpose of the viral neuraminidase protein of infl uenza virus, therefore stopping the virus from replicating through budding from the host cell has been shown to have hindrance against virus. The neuraminidase enzyme is a glycoside hydrolyses enzyme that is shown on the exterior. It allows the virus to be free from the host cell and slice sialic acid groups from glycoproteins and is necessary for infl uenza virus reproduction. Methods: This study concentrates on the in silico virtual screening and molecular docking examination for probable neuraminidase blockers by peramivir like compounds recovered by the ZINC database. ADME-Toxicity examination is done by in silico methods. Results: Molecular docking outcomes propose that modifi ed ligand Anamivire have improved binding attraction than peramivir and its derivatives i.e. ZINC3981610, ZINC 40709762. Conclusion: Modifi ed ligand Anamivire is shown to have resistance against neuraminidase enzyme and bioavailability troubles than ZINC3981610, ZINC40709762 and peramivir.
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