A specific and widely accepted protocol for quality controls in DWI is still lacking. The DWI quality assurance protocol proposed in this study can be applied in order to assess the reliability of DWI-derived indices before tackling single- as well as multicenter studies.

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LaMn1−y3+Mny4+O3±d and La0.67R0.33Mn1−y3+Mny4+O3±d (R = Ca, Sr, Ba) phases were synthesized at 350°C by using very reactive, amorphous precursors obtained from the stoichiometric citrate solutions. The chemical process was optimized with respect to the solution concentration, pH, and additives. The precursor reactions were investigated as a function of the cation stoichiometry and the additive by simultaneous thermal and thermogravimetric analysis and X‐ray diffraction. The reaction pathway was found to be independent of the cation stoichiometry, but related to the acid or base additive. The annealing temperature was systematically increased in the 350–1200°C interval and the La0.67Sr0.33MnO3±d properties (i.e., crystal sizes, Mn average valence, Curie temperature, magnetization, magnetic susceptibility) were measured and found to vary consistently as a function of it.

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The aim of this study was to propose and validate across various clinical scanner systems a straightforward multiparametric quality assurance procedure for proton magnetic resonance spectroscopy (MRS). Methods: Eighteen clinical 1.5T and 3T scanner systems for MRS, from 16 centres and 3 different manufacturers, were enrolled in the study. A standard spherical water phantom was employed by all centres. The acquisition protocol included 3 sets of single (isotropic) voxel (size 20 mm) PRESS acquisitions with unsuppressed water signal and acquisition voxel position at isocenter as well as off-center, repeated 4/5 times within approximately 2 months. Water peak linewidth (LW) and area under the water peak (AP) were estimated. Results: LW values [mean(standard deviation)] were 1.4(1.0) Hz and 0.8(0.3) Hz for 3T and 1.5T scanners, respectively. The mean(standard deviation) (across all scanners) coefficient of variation of LW and AP for different spatial positions of acquisition voxel were 43%(20%) and 11%(11%), respectively. The mean(standard deviation) phantom T2 values were 1145(50) ms and 1010(95) ms for 1.5T and 3T scanners, respectively. The mean(standard deviation) (across all scanners) coefficients of variation for repeated measurements of LW, AP and T2 were 25%(20%), 10%(14%) and 5%(2%), respectively. Conclusions: We proposed a straightforward multiparametric and not time consuming quality control protocol for MRS, which can be included in routine and periodic quality assurance procedures. The protocol has been validated and proven to be feasible in a multicentre comparison study of a fairly large number of clinical 1.5T and 3T scanner systems.