Improvement of colon cancer diagnosis is a very important medical problem. Methods of fluorescence diagnosis (FD) with 5-aminolevulinic acid (5-ALA) have been used in detection of early cancer on the surface of mucosa. The objective of the study was to estimate the effectiveness of FD with 5-ALA in the detection of malignant lesions in the colon. From 2008 to 2010 full examinations have been performed in 78 patients suffering from colon polyps. For the study we used drug Alasens based on 5-ALA. Fluorescence colonoscopy with Alasens was made using the visual assessment of fluorescence images in combination with local fluorescence spectroscopy. The results of FD were compared with those of final histopathological study. The application of the method during colonoscopy allows specifying diagnosis, identifying areas of colon tumors transformation, and also showing a place for targeted biopsy. Sensitivity and specificity of FD with Alasens were 94.9% and 62.5%, respectively. The application of local fluorescence spectroscopy as a step of the combined approach allows increasing the specificity of fluorescence colonoscopy from 62.5% up to 93.7%.
Objective: Methods of fluorescence diagnosis (FD) with 5-aminolevulinic acid (5-ALA) have frequently been used for the detection of early cancer on the surface of the mucosa and skin. The objective of this study was to estimate the effectiveness of FD using Alasens (5-ALA) for the detection of malignant lesions in the colon. Material and methods: In the article, our experience of fluorescence colonoscopy is represented using Alasens (5-ALA) in 78 patients with colonic polyps. FD was performed using the visual assessment of fluorescence images in combination with local fluorescence spectroscopy. Results: The sensitivity and specificity of FD with Alasens was 94.9 % and 62.5 % , respectively. The application of local fluorescence spectroscopy as a step of the combined approach allows the specificity to be increased from fluorescence colonoscopy from 62.5 % up to 93.7 % .Ziel: Methoden der Fluoreszenzdiagnostik (FD) mit 5-Aminol ä vulins ä ure (5-ALA) werden vielfach zum Nachweis von Krebsvorstufen an der Oberfl ä che der Schleimhaut und Haut eingesetzt. Das Ziel dieser Studie war es, die Effektivit ä t der FD mittels Alasens (5-ALA) zum Nachweis von malignen L ä sionen im Darm zu evaluieren. Material und Methoden: Im vorliegenden Artikel werden unsere Erfahrungen beim Einsatz der FluoreszenzKoloskopie mittels Alasens (5-ALA) bei 78 Patienten mit Kolonpolypen pr ä sentiert. Die FD wurde mittels visueller Beurteilung der Fluoreszenzbilder in Kombination mit lokalen Fluoreszenzspektroskopie-Messungen durchgef ü hrt.Ergebnisse: Sensitivit ä t und Spezifit ä t der FD mit Alasens lagen bei 94,9 % und 62,5 % . Die Anwendung der lokalen Fluoreszenzspektroskopie als ein Schritt des kombinierten Ansatzes f ü hrte zu einer Erh ö hung der Spezifit ä t der Fluoreszenz-Koloskopie von 62,5 % auf 93,7 % . Schl ü sselw ö rter: Alasens; Kolonpolyp; Darmkrebs; endoskopische Diagnostik; Protoporphyrin IX.
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