Acceleration
of gelation in the biological environment and improvement
of overall biological properties of a hydrogel is of enormous importance.
Biopolymer stabilized gold (Au) nanoparticles (NPs) exhibit cytocompatibility
and therapeutic activity. Hence, in situ gelation and subsequent improvement
in the property of a hydrogel by employing Au NPs is an attractive
approach. We report that stable Au NPs accelerate the conventional
nucleophilic substitution reaction of activated halide-terminated
poly(ethylene glycol) and tertiary amine functional macromolecules,
leading to the rapid formation of injectable nanocomposite hydrogels
in vivo and ex vivo with improved modulus, cell adhesion, cell proliferation,
and cytocompatibility than that of a pristine hydrogel. NP surfaces
with low chain grafting density and good colloidal stability are crucial
requirements for the use of these NPs in the hydrogel formation. Influence
of the structure of the amine functional prepolymer, the spacer connecting
the halide leaving groups of the substrate, and the structure of the
stabilizer on the rate promoting activity of the NPs have been evaluated
with model low-molecular-weight substrates and macromolecules by 1H NMR spectroscopy, rheological experiments, and density functional
theory. Results indicate a significant effect of the spacer connecting
the halide leaving group with the macromolecule. The Au nanocomposite
hydrogels show sustained co-release of methotrexate, an anti-rheumatic
drug, and the Au NPs. This work provides insights for designing an
injectable nanocomposite hydrogel system with multifunctional property.
The strategy of the use of cytocompatible Au NPs as a promoter provides
new opportunity to obtain an injectable hydrogel system for biological
applications.
This study focuses on the properties and process parameters dictating behavioural aspects of friction stir welded Aluminium Alloy AA6061 metal matrix composites reinforced with varying percentages of SiC and B4C. The joint properties in terms of mechanical strength, microstructural integrity and quality were examined. The weld reveals grain refinement and uniform distribution of reinforced particles in the joint region leading to improved strength compared to other joints of varying base material compositions. The tensile properties of the friction stir welded Al-MMCs improved after reinforcement with SiC and B4C. The maximum ultimate tensile stress was around 172.8 ± 1.9 MPa for composite with 10% SiC and 3% B4C reinforcement. The percentage elongation decreased as the percentage of SiC decreases and B4C increases. The hardness of the Al-MMCs improved considerably by adding reinforcement and subsequent thermal action during the FSW process, indicating an optimal increase as it eliminates brittleness. It was seen that higher SiC content contributes to higher strength, improved wear properties and hardness. The wear rate was as high as 12 ± 0.9 g/s for 10% SiC reinforcement and 30 N load. The wear rate reduced for lower values of load and increased with B4C reinforcement. The microstructural examination at the joints reveals the flow of plasticized metal from advancing to the retreating side. The formation of onion rings in the weld zone was due to the cylindrical FSW rotating tool material impression during the stirring action. Alterations in chemical properties are negligible, thereby retaining the original characteristics of the materials post welding. No major cracks or pores were observed during the non-destructive testing process that established good quality of the weld. The results are indicated improvement in mechanical and microstructural properties of the weld.
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