Abstract.Lactobacillus plantarum bacteria is one kind of environmental friendly lactat acid. It's not phatogenic and could slowed down the growth of phatogen bacteria. It also has a function as probiotic. This research purpose is to find the best dose and influence of L. plantarum bacteria in Patin Jambal fish's hispathology and hemathology that infected with Edwardsiella tarda bacteria. The cause of L. Plantarum submersion is to increase the immune system in Patin jambal (P. djambal) with 10 3 , 10 8 and 10 13 cfu.ml -1 dose in one week. The next step is given infection with E. tarda.submersion. During the infection blood is taken from all subjects to count erythrocytes, leucocytes, hematocrit and hemoglobin during this hour: 0,12,24,36. After three days of infection, sample are taken from liver, kidney and gill to observe the tissue and damage score. The next step is doing statistic analyze using F (ANOVA) test based on completely randomized design. Result analysis show different result ( F count>F table). It can be concluded that L. plantarum bacteria give the best result for histopatology and hematology in Patin Djambal fish (infected with E. tarda bacteria with best dose in B 10 8 cfu.ml -1.)
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