Hemoglobin causes brain edema, at least in part, through its degradation products. Limiting hemoglobin degradation coupled with the use of iron chelators may be a novel therapeutic approach to limit brain edema after ICH.

Rates of axis I disorders were lower than reported in previous studies. Few homicide defendants were in psychiatric treatment at the time of the crime, suggesting limited opportunities for prevention by mental health providers.

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The percentage of injecting opioid users with continuous abstinence from weeks 21-24 was greater with 300/ 300mg (34%) than 300/100mg (18%); among non-injecting users, the percentage of participants with continuous abstinence was 28% in both dose groups Conclusions: Results from this subgroup analysis suggest that injecting opioid users may benefit from the higher (300/300mg) maintenance dose of RBP-6000.

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