This study used positron-emission tomography to examine cerebral metabolic rates of glucose (CMRG) in 17 patients with DSM III-R diagnoses of personality disorder. Within the group of 17 personality disorder patients, there was a significant inverse correlation between a life history of aggressive impulse difficulties and regional CMRG in the frontal cortex of the transaxial plane approximately 40 mm above the canthomeatal line (CML) (r = -.56, P = 0.17). Diagnostic groups included antisocial (n = 6), borderline (n = 6), dependent (n = 2), and narcissistic (n = 3).KEY WORDS: Positron-emission tomography; Cerebral glucose metabolism; Personality disorder; Borderline personality disorder; Antisocial personality disorder; Regional cerebral metabolic rate of glucose Cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) has been shown to inversely correlate with a life history of aggressive impulse diffIculties in patients with personality disorder diagnoses (Brown et al. 1979). This initial study examined 26 patients from nine differ ent personality disorder diagnostic groups. A subse-
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