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We present a comprehensive global catalog of the geomorphological features with clear or potential relevance to subsurface ice identified during the Dawn spacecraft's primary and first extended missions at Ceres. We define eight broad feature classes and describe analyses supporting their genetic links to subsurface ice. These classes include relaxed craters; central pit craters; large domes; small mounds; lobate landslides and ejecta; pitted materials; depressions and scarps; and fractures, grooves, and channels. Features in all classes are widely distributed on the dwarf planet, consistent with multiple lines of observational evidence that ice is a key component of Ceres' crust. Independent analyses of multiple feature types suggest rheological and compositional layering may be common in the upper ~10 km of the crust. Clustering of features indicates that ice concentration is heterogeneous on nearly all length scales, from ~1 km to hundreds of kilometers. Impacts are likely the key driver of heterogeneity, causing progressive devolatilization of the low latitude and midlatitude crust on billion‐year timescales but also producing localized enhancements in near surface ice content via excavation of deep ice‐rich material and possible facilitation of cryomagmatic and cryovolcanic activity. Impacts and landslides may be the dominant mechanism for ice loss on modern Ceres. Our analysis suggests specific locations where future high‐resolution imaging can be used to probe (1) current volatile loss rates and (2) the history of putative cryomagmatic and cryovolcanic features. The Cerean cryosphere and its unique morphology promise to be a rich subject of ongoing research for years to come.

Leri-Weill dyschondrosteosis (LWD) (MIM 127300) is a dominantly inherited skeletal dysplasia characterized phenotypically by Madelung wrist deformity, mesomelia, and short stature. LWD can now be defined genetically by haploinsufficiency of the SHOX (short stature homeobox-containing) gene. We have studied 21 LWD families (43 affected LWD subjects, including 32 females and 11 males, ages 3-56 yr) with confirmed SHOX abnormalities. We investigated the relationship between SHOX mutations, height deficit, and Madelung deformity to determine the contribution of SHOX haploinsufficiency to the LWD and Turner syndrome (TS) phenotypes. Also, we examined the effects of age, gender, and female puberty (estrogen) on the LWD phenotype. SHOX deletions were present in affected individuals from 17 families (81%), and point mutations were detected in 4 families (19%). In the LWD subjects, height deficits ranged from -4.6 to +0.6 SD (mean +/- SD = -2.2 +/- 1.0). There were no statistically significant effects of age, gender, pubertal status, or parental origin of SHOX mutations on height z-score. The height deficit in LWD is approximately two thirds that of TS. Madelung deformity was present in 74% of LWD children and adults and was more frequent and severe in females than males. The prevalence of the Madelung deformity was higher in the LWD vs. a TS population. The prevalence of increased carrying angle, high arched palate, and scoliosis was similar in the two populations. In conclusion, SHOX deletions or mutations accounted for all of our LWD cases. SHOX haploinsufficiency accounts for most, but not all, of the TS height deficit. The LWD phenotype shows some gender- and age-related differences.

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