A review of reactions scaled in the GMP facilities at the Pfizer-Groton site was undertaken. Reactions were categorized into
one of seven categories: carbon−carbon bond formation,
carboxylic acid derivative interconversion, carbon−nitrogen
bond formation, carbon−oxygen bond formation, red-ox, salt
formation/resolution, and other. Reactions scaled from 1997 to
2002 were compared to chemistry scaled from 1985 to 1996 to
look for changes in the nature of chemistry being scaled between
the two time periods. Reactions were further subcategorized
within those categories, and some interesting trends were noted.
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