Dental pulp vitality is a desideratum for preserving the health and functionality of the tooth. In certain clinical situations that lead to pulp exposure, bioactive agents are used in direct pulp-capping procedures to stimulate the dentin-pulp complex and activate reparative dentinogenesis. Hydraulic calcium-silicate cements, derived from Portland cement, can induce the formation of a new dentin bridge at the interface between the biomaterial and the dental pulp. Odontoblasts are molecularly activated, and, if necessary, undifferentiated stem cells in the dental pulp can differentiate into odontoblasts. An extensive review of literature was conducted on MedLine/PubMed database to evaluate the histological outcomes of direct pulp capping with hydraulic calcium-silicate cements performed on animal models. Overall, irrespective of their physico-chemical properties and the molecular mechanisms involved in pulp healing, the effects of cements on tertiary dentin formation and pulp vitality preservation were positive. Histological examinations showed different degrees of dental pulp inflammatory response and complete/incomplete dentin bridge formation during the pulp healing process at different follow-up periods. Calcium silicate materials have the ability to induce reparative dentinogenesis when applied over exposed pulps, with different behaviors, as related to the animal model used, pulpal inflammatory responses, and quality of dentin bridges.
Recurrent implantation failure refers to a failure to achieve a clinical pregnancy after transfer of atleast four good-quality embryos in a minimum of three fresh or frozen cycles in a woman under theage of 40 years. We present this retrospective study, in which we proposed local endometrial injuryfor the management of the uterine factors in the case of 30 couples with recurrent implantationfailure. Our conclusion was that local endometrial injury improved the clinical pregnancy rate forthese couples, especially when the study population met specific criteria.
Recurrent implantation failure is represented by the failure to achieve a clinical pregnancy after transfer of at least 4 good-quality embryos in a minimum of 3 fresh or frozen cycles in a woman under the age of 40 years. One of the recent approaches in studying the window of implantation was building the expression profile of the genes of the endometrial cells. We performed a retrospective study which investigated if endometrial receptivity tests improved the outcomes of IVF procedures in patients with recurrent implantation failure. We enrolled 47 couples with RIF and divided them in 2 groups: the first group of 22 couples performed the ERA test and the embryo transfer according to the result of the test; the second group of 27 couples had the embryo transfer done without the ERA test. Our conclusion was that the ERA test did not improve the outcomes for patients with recurrent implantation failure.
Objectives. Study of predictive factors of outcome in assisted reproductive technologies. Material and methods. The retrospective study on a sample that contains information about 1,121 cycles of embryo transfer (ET) from oocytes and sperm autologous procedures. To quantify the relationship between indicators of success and influence factors, a multivariate analysis were used for factors affecting probability of pregnancy (biochemical or clinical) with in vitro fertilization in relation with 14 independent variables (factorial explanatory). Results. Variables with positive influence correlated with biochemical or clinical pregnancy were identified as: type of medication for ovarian stimulation, age of embryo at the day of transfer, number of days of stimulation, number of retrieved oocytes, female age. Conclusion. Study of risk factors and their influence on the success of assisted reproduction technologies may offer new information and could change practice in the field of in vitro fertilization (IVF). Female age, number of days of stimulation and number of retrieved oocytes are predictors for the chance of pregnancy in IVF treatments. More extensive studies are needed, especially studies that focus on the analysis of factors related to embryo quality as predictors of pregnancy in IVF.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.