Lung cancer is the leading cause of cancer-related deaths worldwide. Despite growing efforts for its early detection by screening populations at risk, the majority of lung cancer patients are still diagnosed in an advanced stage. The management of lung cancer has dramatically improved in the last decade and is no longer based on the “one-fits-all” paradigm or the general histological classification of non-small cell versus small cell lung cancer. Emerging options of targeted therapies and immunotherapies have shifted the management of lung cancer to a more personalized treatment approach, significantly influencing the clinical course and outcome of the disease. Molecular biomarkers have emerged as valuable tools in the prognosis and prediction of therapy response. In this review, we discuss the relevant biomarkers used in the clinical management of lung tumors, from diagnosis to prognosis. We also discuss promising new biomarkers, focusing on non-small cell lung cancer as the most abundant type of lung cancer.
Pandemija COVID-19 veoma je negativno uticala kako na profesionalni, tako i na rekreativni sport u svakom njihovom segmentu. Tokom 120 godina održavanja modernih Olimpijskih igara prateći događaji diktirali su povećanje mera bezbednosti na njima, a posledično i povećanje bezbednosnih zahteva. Do danas se terorizam, kao pretnja celom svetu, pa i Olimpijskim igrama svakako smatrao prioritetnom opasnošću, pred kojom se se sve svetske bezbednosne agencije udruživale u cilju njegovog sprečavanja. Međutim, svedoci smo da se prvi put suočavamo sa novom opasnošću po bezbednost učesnika Olimpijskih igara u vidu pandemije COVID-19, zbog koje je održavanje Igara odloženo za ovu godinu. Predmet ovog istraživanja se odnosi na menadžment sportskih organizacija i organizacionog komiteta za Olimpijske igre u Tokiju pod uticajem COVID-19. Cilj istraživanja je da se kroz analizu rada menadžmenta sportskih organizacija i komiteta sagleda i razume aktuelni problem pandemije COVID-19 i da se kreirane i preduzete mere usvoje i primene i kod organizovanja drugih velikih sportskih događaja. Rezultati rada ukazuju da su sportske organizacije veoma ozbiljno pristupile rešavanju problema, odnosno njihovo angažovanje ukazuje da su mnogobrojnim protokolima i preporukama pokušali da smanje rizik od mogućeg zaražavanja virusom COVID-19 na najmanju moguću meru.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.