RESUMO -O beber problemático é recorrente entre universitários e está associado a inúmeras conseqüências negativas. Portanto, é importante compreender os fatores de risco para este fenômeno. Examinou-se a relação entre expectativas sobre os efeitos do álcool e o padrão de beber de risco em universitários. Os participantes foram 165 universitários, com média de 22 anos (dp=2,5) que responderam aos inventários AUDIT e IECPA. Constatou-se que 44% dos participantes eram consumidores de risco e que 48% possuíam expectativas positivas altas. Entre elas, facilitação das intersações sociais, diminuição e/ou fuga de emoções negativas, ativação e prazer sexual, efeitos positivos na atividade e humor e na avaliação de si mesmo. Houve correlação entre beber problemático e expectativas positivas. Investigar a relação entre padrão de uso e expectativas sobre os efeitos do álcool favorece o planejamento de intervenções terapêuticas e estratégias preventivas mais precisas que visem a reduzir os riscos do beber problemático entre universitários.Palavras-chave: álcool; expectativas; universitários. Expectations and Problematic Drinking among College StudentsABSTRACT -Problematic drinking is recurrent among college students and is associated with a variety of negative consequences. Therefore, it is important to understand risk factors for this phenomenon. The present study assessed the relationship between expectations over alcohol effects and risk drinking pattern among college students. Participants were 165 college students with average age of 22 years old (dp= 2,5) who responded to the AUDIT and IECPA inventories. Results indicated that 44% of the participants were risk consumers and 48% had high positive expectations, among them facilitation of social interaction, decrease and/or escape of negative emotions, enhanced sexual pleasure, positive effects on activity, mood and self evaluation. There was a correlation between problematic drinking and positive expectations. To investigate the relationship between pattern of use and expectations over alcohol effects favours planning of therapeutical interventions and more precise preventive strategies aiming at reducing the risks of problematic drinking among college students.

The aim of this study was to compare three groups of Brazilian psychoactive substance (PAS) abuse patients (crack cocaine users, cocaine snorters, and non-cocaine PAS users) in terms of psychiatric comorbidities and severity of psychosocial problems. A cross-sectional, multi-center study was conducted at five Brazilian research centers. A total of 738 current PAS abusers seeking specialized treatment (outpatient and inpatient clinics) were assessed using the sixth version of the Addiction Severity Index (ASI-6): 293 patients using crack cocaine were compared with 126 using powder cocaine and 319 using non-cocaine PAS (mostly alcohol and marijuana). Psychiatric comorbidities were assessed in a smaller sample (290 cases), originating from three of the centers, using the Mini International Neuropsychiatric Interview Plus (MINI-Plus). Crack and powder cocaine users were significantly younger than non-cocaine PAS users (31.1 ± 8.1 and 32.9 ± 8.8 vs. 42.4 ± 12, respectively; p < .001). Crack users presented a higher rate of antisocial personality disorder (25%) than powder cocaine (9%) and non-cocaine PAS users (9%), even when adjusted for confounding factors (Pr = 2.6; 95% CI 1.10-6.40). According to ASI-6 summary scores, crack users presented a significantly higher rate of occupational, family, and legal problems and reported more illegal and violent activities such as burglary and theft (23%) and threatening or assaulting (32%) than non-cocaine PAS users. Our findings, combined with the recent increase observed in the prevalence of crack use in Brazil, highlight the severity of psychiatric symptoms and psychosocial problems related to this powerful drug and corroborate the already suggested association between crack/cocaine, violence, and legal problems. Treatment programs for crack users should routinely consider the possibility of associated psychiatric comorbidities, such as antisocial personality disorder, which may affect treatment outcomes.

Lisiane Bizarro Araujo ae RESUMO. A avaliação em psicoterapia constitui um desafio para pesquisadores e clínicos. Esta revisão crítica sobre possibilidades de avaliação de processo e resultado em psicoterapia estimula o debate sobre a incorporação da prática clínica baseada em evidências como meio de obter informação científica quanto à adequação da intervenção terapêutica. Através de estudos sobre a avaliação do processo psicoterápico é possível elucidar conexões entre o tratamento psicológico e seus efeitos. Desta forma, torna-se possível identificar mecanismos de ação terapêutica e estratégias que podem potencializar o processo de mudança. Este debate poderá favorecer a aproximação entre pesquisa e prática clínica. Identificar variáveis das quais pode depender a eficácia/efetividade do tratamento psicoterápico repercute no aprimoramento do treinamento de psicólogos em formação e no delineamento de intervenções custo-efetivas. Palavras-chave: Tratamento psicoterápico, eficácia e efetividade, prática baseada em evidência.

Objective: To assess the characteristics of alcohol and drug users who seek treatment at the Brazilian Unified Health System in Brazil. Method: A multicenter cross-sectional study involving five clinical and research centers located in four Brazilian state capitals was conducted with 740 in-and outpatients. The only exclusion criterion was the presence of neurological or severe psychiatric symptoms at the moment of the interview. The Addiction Severity Index (ASI-6) and the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) were used to assess the severity of substance use and the problems related. Results: There were significantly more men than women in the sample; mean age was 36 years. The drug most frequently used at all sites was alcohol (78%), followed by cocaine/crack (51%). Alcohol was the drug that most commonly motivated treatment seeking, at all centers. ASI-6 Summary Scores for Recent Functioning (SS-Rs) were quite similar among centers. SS-Rs were compared between users who had never received treatment for psychoactive substance abuse (n = 265, 36.1%) and those who had already been treated at one or more occasions (n = 470, 63.9%). This analysis revealed significant differences between the groups in the drug, psychiatric symptoms, legal, and family/ social problems areas (p < 0.05). Conclusion: Our findings confirm previous evidence suggesting that the management of patients seeking drug abuse treatment should take several different aspects into consideration, e.g., education, employment, and family relationships, which often appear as areas of concern for these individuals. Keywords: Substance abuse, treatment, multicenter, alcohol, drugs, public health. ResumoObjetivo: Avaliar as características dos usuários de álcool e drogas que procuram tratamento no Sistema Único de Saúde. Método: Estudo transversal multicêntrico envolvendo cinco centros clínicos/de pesquisa localizados em quatro capitais brasileiras foi realizado com 740 pacientes hospitalizados e ambulatoriais. O único critério de exclusão foi a presença de sintomas neurológicos ou psiquiátricos graves no momento da entrevista. A Escala de Gravidade de Dependência (Addiction Severity Index, ASI-6) e o teste ASSIST (Alcohol, Smoking and Substance Involvement Screening Test) foram utilizados para avaliar a severidade do uso de substância e problemas relacionados. Resultados: Houve significativamente mais homens do que mulheres na amostra; a idade média foi de 36 anos. A droga mais usada em todos os centros foi o álcool (78%), seguido de cocaína/ crack (51%). O álcool foi a droga que mais motivou procura por tratamento, em todos os centros. Os Escores Resumidos da ASI-6 para Funcionamento Recente (SS-Rs) foram bastante similares nos centros. SS-Rs foram comparados entre usuários que nunca haviam recebido tratamento para abuso de substâncias (n = 265, 36,1%) e aqueles que já haviam sido tratados uma ou mais vezes (n = 470, 63,9%). Foram observadas diferenças significativas entre os grupos nas áreas de droga, sintomas psiq...

Objectives: Depressive symptoms are associated with worse outcomes in patients with bipolar disorder (BD). However, scarce data are available regarding neurocognitive profiles across different areas of functioning among BD patients with moderate and severe depression. Our objective was to assess cognition and global functioning in a group of patients with bipolar depression. Methods: Data were available for 100 patients with bipolar depression (78% female) and 70 controls (64% female) paired by age and education level. Cognitive function was assessed with a neuropsychological test battery. Functioning was assessed with the Functioning Assessment Short Test. Results: In patients, severe depression was associated with poorer cognitive performance on measures of executive function. Patients with severe depression showed worse global functioning than those with moderate depression (z = 2.54, p = 0.011). In patients with severe depression, lower global functioning was associated with lower scores in working memory (r = -0.200, p = 0.010), and executive function (r = -0.210, p = 0.007; and r = 0.293, p o 0.001). Conclusion: Our findings suggest cognitive impairment and global functioning impairment are associated with the severity of depressive symptoms in bipolar depression. Intensive treatment of depressive symptoms in patients with BD is crucial to improve cognitive functioning and, consequently, functional outcomes.

Causal attribution among women with breast cancer was studied. The study included 157 women outpatients with breast cancer. A form for sociodemographic and clinical data and the Revised Illness Perception Questionnaire (IPQ-R) were used. The results showed that women attributed breast cancer primarily to psychological causes, which does not correspond to known multifactorial causes validated by the scientific community. Providing high quality, patient-centered care requires sensitivity to breast cancer women's beliefs about the causes of their cancer and awareness of how it can influence patient's health behaviors after diagnosis. If women with breast cancer attribute the illness to modifiable factors then they can keep a healthy lifestyle, improving their recovery and decrease the probability of cancer recurrence after diagnosis.

A b s t r a c t Objective: Studies have shown signs of brain damage caused by different mechanisms in cocaine users. The serum neuron specific enolase and S100B protein are considered specific biochemical markers of neuronal and glial cell injury. This study aimed at comparing blood levels of S100B and NSE in chronic cocaine users and in volunteers who did not use cocaine or other illicit drugs. Method: Twenty subjects dependent on cocaine but not on alcohol or marijuana, and 20 non-substance using controls were recruited. Subjects were selected by consecutive and non-probabilistic sampling. Neuron specific enolase and S100B levels were determined by luminescence assay. Results: Cocaine users had significantly higher scores than controls in all psychiatric dimensions of the SCL-90 and had cognitive deficits in the subtest cubes of WAIS and the word span. Mean serum S100B level was 0.09 ± 0.04 μg/l among cocaine users and 0.08 ± 0.04 μg/l among controls. Mean serum neuron specific enolase level was 9.7 ± 3.5 ng/l among cocaine users and 8.3 ± 2.6 ng/l among controls. Conclusions: In this first study using these specific brain damage markers in cocaine users, serum levels of S100B and neuron specific enolase were not statistically different between cocaine dependent subjects and controls.Descriptors: Cocaine; Cognitive science; Cognition disorders; Symptoms, psychotic; Neuron specific enolase Resumo Objetivo: Estudos têm demonstrado sinais de lesão cerebral causadas por diferentes mecanismos em usuários de cocaína. A enolase sérica neurônio-específica e a proteína S100B são consideradas marcadores bioquímicos específicos de lesão neuronal e glial. Este estudo objetivou comparar os níveis sangüíneos de S100B e enolase sérica neurônio-específica em usuários crônicos de cocaína e em voluntários que não usam cocaína ou outras drogas ilícitas. Método: Vinte sujeitos dependentes de cocaína, mas não dependentes de álcool, maconha ou outra droga, e 20 sujeitos controles não usuários de drogas foram recrutados. Os sujeitos foram selecionados por amostragem consecutiva e não-probabilística e os níveis de enolase neurônio-específica e S100B foram determinados por ensaio de luminescência. Resultados: Os usuários de cocaína tiveram escores significativamente maior que os controles em todas as dimensões psiquiátricas do SCL-90 e apresentaram prejuízos cognitivos no subteste cubos do WAIS e no span de palavras. Os níveis de S100B foram em média 0,09 ± 0,04 μg/l nos usuários de cocaína e 0,08 ± 0,04 μg/l nos controles. Os níveis de enolase neurônio-específica foram em média 9,7 ± 3,5 ng/l nos usuários e 8,3 ± 2,6 ng/l nos controles. Conclusão: Neste primeiro estudo utilizando esses marcadores específicos de lesão cerebral em usuários de cocaína, os níveis séricos de S100B e enolase específica do neurônio não foram significativamente diferentes entre dependentes de cocaína e controles.

Resumo. O tabagismo é um comportamento refratário, pois, apesar de seus conhecidos efeitos negativos, poucos fumantes conseguem parar de fumar. Caracterizou-se o processo de cessação do tabagismo de 62 ex-fumantes (m = 50 anos, dp = 11), de ambos os sexos, com oitos anos de abstinência em média. Eles responderam um questionário do comportamento de fumar retrospectivo, com 16 questões sobre histórico prévio de consumo do cigarro, processo de cessação do tabagismo e manutenção da abstinência. Os dados foram analisados através de estatística descritiva de categorias defi nidas. A maior parte dos participantes havia feito pelo menos três tentativas prévias para parar de fumar, motivados por questões de saúde, e referiu não sentir mais fi ssura. Os fatores mais relacionados à recaída foram fi ssura, stress, sintomas de abstinência e ganho de peso. Festas, uso de álcool e café, solidão e stress foram considerados gatilhos para fi ssura. Diversas estratégias cognitivas e comportamentais para a manutenção da abstinência foram utilizadas. Identifi car variáveis associadas à abstinência prolongada de nicotina pode contribuir para aumentar a efi cácia do auxílio ao fumante, a adesão ao tratamento e as taxas de remissão do tabagismo.Palavras-chave: dependência de nicotina, recaída, uso de cigarro. Abstract.Smoking is a refractory behavior, despite its well-known negative eff ects; few quitt ers are successful. The smoking cessation process of 62 ex-smokers (m = 50, SD = 11) of both genders, with eight years of abstinence on average, was characterized. Most of them had already done at least three previous att empts to quit smoking, motivated by health issues, and said they no longer feel craving. Craving, stress, withdrawal symptoms and weight gain were related by them to relapse. Parties, alcohol and coff ee use, loneliness and stress were considered triggers for craving. The use of cognitive and behavioral strategies for the maintenance of abstinence was highly reported by them. Identifying variables associated with prolonged nicotine abstinence may contribute to increase the eff ectiveness of aid to smoking, treatment adherence and remission rates of smoking.Keywords: nicotine addiction, relapse, cigarett e consumption. Características do processo de cessação do tabagismo na abstinência prolongadaCharacteristics of the smoking cessation process in prolonged nicotine abstinence