A reação de aminas com ditiocicloexilidenos é uma reação geral para a síntese de diaminometilenobarbituratos. Quando diaminas do tipo H 2 N-(CH 2 ) n -NH 2 são utilizadas como nucleófilos os produtos majoritários de reação são compostos bicíclicos, cujos rendimentos aumentam conforme n diminui, n = 2, 3, 4. Quando n = 6, obtém-se altos rendimentos (80-90%) de novos compostos macrocíclicos de 18 e 27 membros. As atribuições dos deslocamentos químicos de 1 H e 13 C RMN de todos os produtos são discutidas.The reaction of amines with dithiocyclohexylidenes is a general reaction for the synthesis of diaminomethylidene barbiturates. When diamines of the type H 2 N-(CH 2 ) n -NH 2 are used as nucleophiles bicyclic compounds are the major reaction products, with yields increasing as n decreases, n = 2, 3, 4. When n = 6, macrocyclic compounds, novel 18 and 27 member rings, are obtained in very good yields. The 1 H and 13 C NMR assignment for all products is discussed.
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