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Background: Development of biodegradable and biocompatible films based on the protein polymer with strong antibacterial activities is gradually obtained extensive concern in the world. Objectives: In this study, improvement of chitosan film properties incorporated with Trachyspermum ammi essential oil as a potential antioxidant/antibacterial wound dressing was investigated. Materials and Methods: Gelatin films were prepared from gelatin solutions (10% w/v) containing Trachyspermum ammi essential oil TAM (2, 4, 6 and 8% w/w), glycerol (25% w/w) as plasticizer, and glutaraldehyde (2% w/w) as cross-linker. The mechanical, water solubility, water swelling, water vapor permeability, antioxidant and antibacterial properties of the films were measured according to the American Society for Testing and Materials. Results: Gelatin films exhibited good tensile strength and elongation at break, water solubility, swelling, and water vapor permeability. Incorporation of TAM into the gelatin films caused a significant decrease in tensile strength and swelling, and a significant increase in elongation at break, water solubility, water vapor permeability and whiteness of the films. Gelatin films exhibited low antioxidant activity while gelatin films incorporated with TAM exhibited excellent antioxidant properties. The films incorporated with TAM also exhibited excellent antibacterial properties against both Gram-positive and Gram-negative bacteria. Conclusions: Our results suggest that the gelatin/TAM films could be used as a very attractive alternative to traditional materials for different biomedical applications.

Background: Development of biodegradable and biocompatible films based on protein polymer with strong antioxidant and antibacterial activities has gradually obtained extensive concern in the world. In this study, the improvement of gelatin film properties incorporated with Ferula assa-foetida essential oil (FAO) as a potential antioxidant/antibacterial wound dressing film was investigated. Materials and Methods: Gelatin films were prepared from gelatin solutions (10% w/v) containing different concentration of FAO. The effect of FAO addition on water solubility, water swelling, water vapor permeability, mechanical behavior, light barrier properties as well as antioxidant and antibacterial activities of the films were examined. Results: Water solubility, water swelling and water vapor permeability for pure gelatin films were 29 ± 1.6%, 396 ± 8%, 0.23 ± 0.018 g.mm/m2.h, respectively. Incorporation of FAO into gelatin films caused a significant decrease in swelling and increase in solubility and water vapor permeability. Tensile strength, elastic modulus and elongation at break for pure gelatin films were 4.2 ± 0.4 MPa, 5.8 ± 4.2 MPa, 128 ± 8 %, respectively. Incorporation of FAO into gelatin films caused a significant decrease in tensile strength and elastic modulus and increase in elongation at break of the films. Gelatin film showed UV-visible light absorbance ranging from 280 to 480 nm with maximum absorbance at 420 nm. Gelatin/FAO films also exhibited excellent antioxidant ad antimicrobial activities. Conclusions: Our results suggested that gelatin/FAO films could be used as active films due to their excellent antioxidant and antimicrobial features for different biomedical applications including wound-dressing materials.[GMJ.2015;4(2):103-14]

Development of biodegradable and biocompatible films based on the proteinpolymer with strong antibacterial activities is gradually obtained extensive concern in the world. The aim of this study was to evaluate the antioxidant and antibacterial properties of gelatin nano films merged with different concentrations of Zataria multiflora essential oil. Gelatin films were prepared from gelatin solutions (10% w/v) containing Zataria multiflora essential oil [ZMO] (2, 4, 6 and 8% w/w), glycerol (25% w/w) as plasticizer, and glutaraldehyde (2% w/w) as cross-linker. The mechanical, water solubility, water swelling, water vapor permeability, antioxidant and antibacterial properties of the films were measured according to the American Society for Testing and Materials. Gelatin films exhibited good tensile strength and elongation at break, water solubility, swelling, and water vapor permeability. Incorporation of ZMO into the gelatin films caused a significant decrease in tensile strength and swelling, and a significant increase in elongation at break, water solubility, water vapor permeability and whiteness of the films. Gelatin films exhibited low antioxidant activity while gelatin films incorporated with ZMO exhibited excellent antioxidant properties. The films incorporated with ZMO also exhibited excellent antibacterial properties against both Gram-positive and Gram-negative bacteria. Our results suggest that the gelatin/ZMO films could be used as a very attractive alternative to traditional materials for different biomedical applications.

Background: Manufacturing Gelatin nano-capsules merged with Ferula assa-foetida essential oil, antioxidant and antibacterial properties to produce drugs with properties targeted drug delivery to the body. Objectives: In this study, we proved that gelatin nano-capsules grafted with F. assa-foetida essential oil have excellent physical, well as good antioxidant and antibacterial activity, which is suitable for producing nano-capsules of antioxidant antibacterial drug. Materials and Methods: In this experimental study, gelatinnano-capsules were prepared from gelatin solutions (10% w/v) containing F. assa-foetida essential oil (FAO) (2, 4, 6 and 8% w/w), glycerol (25% w/w) as plasticizer and glutaraldehyde (2% w/w) as cross-linker. The morphology, antioxidant and antibacterial properties of the nano-capsules were achieved according to American Society for Testing and Materials. Results: Gelatin nano-capsules exhibited low antioxidant activity while gelatin nano-capsules incorporated with FAO exhibited excellent antioxidant properties. The nano-capsules incorporated with FAO also exhibited excellent antibacterial properties against both Grampositive and Gram-negative bacteria. Conclusions: According to the results, gelatin nano-capsules are good nominations for a variety of antibiotic replacement industrial. The nano-capsules as well as due to the risk of bacterial resistance stay safe. The nano-capsules according to the origin of the whole plant do not have any negative effects on the body.