(1,6a,6b,9,9,12a,14b-heptamethyl 1, 2, 4a, 5, 6, 6a, 6b, 7, 9, 10, 11, 12, 12a, 12b, 13, 14b-hexadecahydropicen-3-yl) propan-2-yl nonanoate. Compound 2 was found to be not pure enough to be characterized. The isolated compounds were also tested for their anti-proliferative activity against breast cancer.
Pyrethrin; derived from natural source (Chrysanthemum cinerariifolium) confirmed as a fundamental nucleus for the development of pyrethroids which ultimately resulted in the outstanding insecticidal activity by targeting the nervous systems of insects. To date, the binding and entry mechanism by which RSV infects respiratory epithelial cells is not still well understood and need to be explored. Notably, pyrethrins have exhibited considerable antiviral potential & thus an effort was made computationally to evaluate the pyrethroids as hopeful inhibitors of Respiratory Syncytial Virus (RSV). Type 1 & type 2 Pyrethroids were subjected to docking simulations by using Maestro 9.2 version (Schrodinger LLC). Cyfluthrin showed better binding interactions against RSV (Glide score: -4.54). Remarkably, it showed two hydrogen bonding interactions with Lys46 (1.82 Å) & Hie151 (2.19 Å) of RSV protein receptor. The decrease in glide score is evidence for greater bond stability with protein. Based on the current findings, these studies in future may act as effective predecessor tool to further validate pyrethroids with wet lab experiments as capable antiviral agents for RSV.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.