BackgroundData, data everywhere. The diversity and magnitude of the data generated in the Life Sciences defies automated articulation among complementary efforts. The additional need in this field for managing property and access permissions compounds the difficulty very significantly. This is particularly the case when the integration involves multiple domains and disciplines, even more so when it includes clinical and high throughput molecular data.Methodology/Principal FindingsThe emergence of Semantic Web technologies brings the promise of meaningful interoperation between data and analysis resources. In this report we identify a core model for biomedical Knowledge Engineering applications and demonstrate how this new technology can be used to weave a management model where multiple intertwined data structures can be hosted and managed by multiple authorities in a distributed management infrastructure. Specifically, the demonstration is performed by linking data sources associated with the Lung Cancer SPORE awarded to The University of Texas MDAnderson Cancer Center at Houston and the Southwestern Medical Center at Dallas. A software prototype, available with open source at www.s3db.org, was developed and its proposed design has been made publicly available as an open source instrument for shared, distributed data management.Conclusions/SignificanceThe Semantic Web technologies have the potential to addresses the need for distributed and evolvable representations that are critical for systems Biology and translational biomedical research. As this technology is incorporated into application development we can expect that both general purpose productivity software and domain specific software installed on our personal computers will become increasingly integrated with the relevant remote resources. In this scenario, the acquisition of a new dataset should automatically trigger the delegation of its analysis.
Distributed denial of service (DDoS) is one of the most persecution network attack techniques to be confronted in recent years. From the definition of DDoS, thousands of network attacks must initiate simultaneously and continuously to achieve a successful DDoS attacking. Therefore, almost all of the information system cannot survive as they confront the DDoS attacks. Although there are a lot of intrusion detection system (IDS) developed, preventing DDoS attack is still difficult and perplexing. In this paper, an early warning system for detecting DDoS attacking has been mounted to a traditional IDS to form a completely system. This early warning system is developed based on the rationale of time delay neural network. In the networking topology, each node is monitored with the deployment of detectors to establish a multilayer architecture. In addition, the activities of each node will be monitored by their neighboring nodes to check whether it is still survival or not mutually. After then, all of the attacking information will be collected and transferred to the expert module for integrating analysis. As those nodes dispatched on the DMZ or between the first and second layer of firewall face some attacking similar as the pattern of DDoS, the kernel expert module which dispatched behind the second firewall will take some feasible actions and initiate the defense strategies to protect the kernel information system. In the meanwhile, those failed nodes will be restarted and act as the role of vanguard to assure the networking under normal operation.
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