BackgroundThe aim of this study was to investigate the influence of body mass index (BMI) on the in vitro fertilization (IVF) treatment outcomes in a cohort of women undergoing their first IVF, using an intracytoplasmic sperm injection (ICSI).MethodsThis retrospective cohort study included 298 cycles from women younger than 38 years old undergoing IVF-ICSI at a university infertility clinic. The treatment cycles were divided into three groups according to the BMI of the women involved: normal weight (18.5 ≤ BMI < 25 kg/m2, 164 cycles), overweight (25 ≤ BMI < 30 kg/m2, 70 cycles), and obese (BMI ≥ 30 kg/m2, 64 cycles). The underweight women (BMI < 18.5 kg/m2) were not included in the analysis due to small sample size (n = 22). The patient characteristics and IVF-ICSI treatment outcomes were compared between the BMI groups.ResultsThe total gonadotropin dose (p <0.001) and duration of stimulation (p = 0.008) were significantly higher in the obese group when compared to the normal BMI group. There were no significant differences across the BMI categories for the other IVF-ICSI cycle outcomes measured, including the number of retrieved oocytes, mature oocytes, embryos suitable for transfer, proportion of oocytes fertilized, and cycle cancellation rates (p >0.05 for each). Additionally, clinical pregnancy, spontaneous abortion, and the ongoing pregnancy rates per transfer were found to be comparable between the normal weight, overweight, and obese women (p >0.05 for each).ConclusionObese women might require a significantly higher dose of gonadotropins and longer stimulation durations, without greatly affecting the pregnancy outcomes.

Objective. Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder affecting 5–10% of women in reproductive age. Insulin resistance, dyslipidemia, glucose intolerance, hypertension, and obesity are metabolic disorders accompanying the syndrome. PCOS is a chronic proinflammatory state and the disease is associated with endothelial dysfunction. In diseases with endothelial damage, hearing in high frequencies are mostly effected in early stages. We evaluated extended high frequency hearing loss in PCOS patients. Material Methods. Forty women diagnosed as PCOS and 25 healthy controls were included in this study. Age and BMI of PCOS and control groups were comparable. Each subject was tested with low (250–2000 Hz), high (4000–8000 Hz), and extended high frequency audiometry (8000–20000). Hormonal and biochemical values including LH, LH/FSH, testosterone, fasting glucose, fasting insulin, HOMA-I, and CRP were calculated. Results. PCOS patients showed high levels of LH, LH/FSH, testosterone, fasting insulin, glucose, HOMA-I, and CRP levels. The hearing thresholds of the groups were similar at frequencies of 250, 500, 1000, 2000, and 4000 Hz; statistically significant difference was observed in 8000–14000 Hz in PCOS group compared to control group. Conclusion. PCOS patients have hearing impairment especially in extended high frequencies. Further studies are needed to help elucidate the mechanism behind hearing impairment in association with PCOS.

The effect of ISSC and early breastfeeding on mothers was documented for the first time in this study. Our results demonstrated ISSC and early breastfeeding during C/S reduce maternal oxidative stress.

Background Acupuncture is commonly used to treat menopausal symptoms and other gynaecological conditions. In this study, the authors aimed to investigate whether acupuncture has an effect on menopausal symptoms and to explore whether this effect is related to changes in hormone levels. Materials and methods A total of 53 postmenopausal women were alternately assigned into two treatment groups: acupuncture (n=27) and sham acupuncture (n=26). Menopausal symptoms were assessed using the Menopause Rating Scale (MRS). The serum oestradiol, follicular stimulating hormone (FSH) and luteinising hormone (LH) levels were measured at baseline and again after the fi rst and last sessions. The Student t test was used for normally distributed data and the Wilcoxon signed rank test for not normally distributed data. The group differences in MRS scores were assessed using non-parametric Mann-Whitney U test. Results After treatment, total MRS, and the somatic and psychological subscale scores were signifi cantly lower in the acupuncture group than the sham group (all p=0.001). The severity of hot fl ushes was found to be signifi cantly decreased after treatment in acupuncture group (p=0.001). In the acupuncture group LH levels were lower and oestradiol levels were signifi cantly higher than sham group (p=0.046 and p=0.045, respectively) after treatment, but there was no difference in FSH levels. Conclusion Acupuncture was effective in reducing menopausal complaints when compared to sham acupuncture and can be considered as an alternative therapy in the treatment of menopausal symptoms. INTRODUCTIONPerimenopause syndrome, referred also as climacteric syndrome, results from the changing of relationship among the hypothalamus, pituitary and ovary during women's ageing process. Those changes take place fi rst in the ovary, then in the hypothalamus and pituitary, which are refl ected as the functional changes in the endocrinological and central nervous system, accompanied with a series of psychological symptoms.1 Oestrogen, either by itself or with progestins is the most consistently effective therapy for these symptoms. However, the Women's Health Initiative and Million Women Study have identifi ed important risk factors (coronary heart disease, stroke, breast and endometrial cancer) associated with hormone replacement therapy (HRT). [3][4][5][6] Those fi ndings have led to an expanded interest in non-hormonal therapies for managing menopausal symptoms. However, there are only limited data to support their use. The common conclusion in reviews regarding to complementary and alternative therapies for the management of menopause related symptoms was that the data were insuffi cient to recommend any alternative therapy and further investigation was still needed.7 8 In the area of complementary and alternative therapies, acupuncture and acupressure treatments are promising, however, the results of published randomised controlled trials of the effect of acupuncture on hormone levels and symptoms in postmenopausal women have been ...

Amaç: Kliniğimizde endometrial örnekleme yapı-lan olgularda, endikasyon ile histopatolojik sonuçlar arasındaki ilişkinin araştırılması. Gereç ve Yöntem:Kliniğimize Ocak 2013-Ocak 2014 tarihleri arasında başvuran ve gebelik dışı herhangibir endikasyonla endometrial örnekleme yapılan 744 olgu retrospektif olarak değerlendirildi. Veriler hastanemiz kadın hastalıkları ve doğum kliniği ve patoloji kliniği arşivinden alındı. İstatistiksel analiz için SPSS 13 programı kullanıldı. Bulgular:Olguların ortalama yaşları 43.6 +/-8.3 idi. Endometrial örnekleme endikasyonları sırasıy-la menometroraji/menoraji (%87), postmenopozal kanama (%9.5), servikal polip (%1.9), myom uteri (%1.6) idi. Histopatolojik sonuçlar ise sırayla proliferatif/sekretuar endometrium (%72.8), endometrial polip (%9.5), basit atipisiz hiperplazi (%7.9), atrofik endometrium (%3.5), endometrit (%3.2), yetersiz materyal (%0.9), endometrium kanseri (%0.8), basit atipili hiperplazi (%0.7), komplex atipili hiperplazi (%0.3), komplex atipisiz hiperplazi (%0.3) idi. Endometrium kanseri görülme oranı postmenapozal kanaması olan hasta grubunda %5.6 ile diğer gruplara oranla anlamlı derecede yüksek bulundu.Sonuç: En sık endometrial örnekleme endikasyonu menoraji/menometroraji iken endometrium kanseri açısından riskli grubun postmenopozal kanamalı olgular olduğu gösterilmiştir. Bu nedenle postmenapozal kanamalı hastalarda ciddi endometrial değerlendirme ve örnekleme yapılmasi gerekir. Ayrıca servikal polip olgularında endometriumunun değer-lendirilmesinin gerektiği sonucuna varılmıştır.Anahtar kelimeler: endometrial örnekleme, anormal uterin kanama, endometrium kanseri ABSTRACT Aims: To evaluate indications and histopathological diagnoses of endometrial samplings in our clinic. Materials-Methods:Seven hundred and fourty four subjects who required endometrial biopsy to be taken for any indication other than pregnancy between January 2013 and January 2014 were included in the study. Data collected retrospectively from Dumlupinar University Evliya Celebi Training and Research Hospital obstetrics and gynecology clinic database and pathology clinic. Statistical analysis of data was performed using SPSS for Windows 13 package programme.Results: Mean age of the subjects was 43.6 ± 8.3. Indications of endometrial sampling were menorrhagia/menometrorrhagia (87%), myoma uteri (1.6%), postmenopausal bleeding (9.5%), cervical polyp (1.9%). Histopathologic diagnoses were as follows: secretory/proliferative endometrium in 72.8%, atrophic endometrium in 3.5%, simple atypical endometrial hyperplasia in 0.7%, simple typical endometrial hyperplasia in 7.9%, complex atypical endometrial hyperplasia in 0.3%, complex typical endometrial hyperplasia in 0.3%, atrophic endometrium in 3.5%, endometrium cancer in 0.8%, and endometrial polyp in 9.5%. Insufficient sampling material was reported in 0.9%. Endometrium cancer was detected in 5.6% of postmenopausal group. Conclusion:The most common endometrial sampling indication was menorrhagia/menometrorrhagia, while endometrium cancer was detec...