Bullous pemphigoid (BP) is an autoimmune disorder, affected the skin and mucous membrane 1 which has some rare, hard-to-diagnosis variants with atypical clinical presentations. 2 Pemphigoid nodularis (PN) is a rare variant of BP with clinical features of prurigo nodularis and serologic profile of BP. 3 It has been hypothesized that antigen liberation due to constant scratching and rubbing of pruritic lesions might lead to this condition. 4 Owing to the rarity of this condition, no long-term, large study has been conducted to assess clinical and laboratory findings of affected patients.Here, we assessed demographic, clinical, histopathological, and serologic profile of Iranian patients suffered from NP in a retrospective study using data retrieved from the clinical records of patients attending the pemphigus clinic of Razi Hospital, which is the main referral center for dermatologic disorders in Iran over a period of 10 years (July 2010-July 2020).
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