Introduction
Angiokeratoma corporis diffusum are benign capillary malformations typically associated with Fabry disease and other lysosomal storage disorders. Only in a few cases they appear in healthy individuals.
Methods and Case
We carried out an exhaustive review of the literature on angiokeratomas and their main clinical, dermoscopy and histological features. Additionally, we reviewed the cases of healthy subjects illustrating the limitations of each case and comparing these results with our case.
Discussion
Angiokeratoma corporis diffusum is mostly related to Fabry disease and other lysosomal storage disorders. However, some cases may occur in apparently healthy individuals. Therefore, there is a increasing interest in its etiology, pathogenesis and clinical evaluation.
Conclusion
This is an academic–clinical review on angiokeratomas and their main implications in daily dermatological practice. Additionally, we report the first case in the literature of angiokeratoma corporis diffusum in a healthy patient with up‐to‐date laboratory methods currently available. The clinician should remember that not all angiokeratoma corporis diffusum occurs with lysosomal storage disorders.
La dermatosis neutrofílica acral (síndrome de Sweet localizado) fue descrita inicialmente como una manifestación cutánea de predominio en el dorso de las manos, con características histopatológicas de una vasculitis leucocitoclástica. Posteriormente se describió la presencia de neutrófilos y los cambios paraclínicos de una dermatosis neutrofílica localizada. Esta entidad se asocia a la presencia de infecciones, enfermedades autoinmunitarias, fármacos y neoplasias. Reportamos el caso de una mujer de 69 años con antecedente de carcinoma papilar de tiroides con nódulos dolorosos en palmas compatibles con síndrome de Sweet localizado.
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