Stainless steel screws and other internal fixation devices are used routinely to stabilize bacteria-contaminated bone fractures from multiple injury mechanisms. In this preliminary study, we hypothesize that a chitosan coating either unloaded or loaded with an antibiotic, gentamicin, could lessen or prevent these devices from becoming an initial nidus for infection. The questions investigated for this hypothesis were: (1) how much of the sterilized coating remains on the screw with simulated functional use; (2) is the unloaded or loaded chitosan coating bacteriostatic and biocompatible; and (3) what amount and rate does an antibiotic elute from the coating? In this study, the gentamicin eluted from the coating at a detectable level during 72 to 96 hours. The coating was retained at the 90% level in simulated bone screw fixation and the unloaded and loaded chitosan coatings had encouraging in vitro biocompatibility with fibroblasts and stem cells and were bacteriostatic against at least one strain of Staphylococcus aureus. The use of an antibiotic-loaded chitosan coating on stainless steel bone screws and internal fixation devices in contaminated bone fracture fixation may be considered after optimization of antibiotic loading and elution and more expanded in vitro and in vivo investigations with other organisms and antibiotics.

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BackgroundWe evaluate the effect of repairing the upper subscapularis tendon at an alternative location on the anterior greater tuberosity above the center of rotation using a reverse shoulder arthroplasty (RSA) muscle model.MethodsWe compared an innovative subscapularis repair on the anterior aspect of the greater tuberosity with the standard repair on the lesser tuberosity in a previously validated digital linear RSA muscle model. Standard repair vs. a new repair datasets were compared for 3 RSA designs. Each model was run through humeral abduction from 0° to 140° in 2.5° increments; the resulting moment arm measurements (model of tendon efficiency) were recorded in millimeters for 3 sections (superior, middle, inferior). An isolated upper two-thirds subscapularis repair to the anterior greater tuberosity was also evaluated (the over-the-top repair).ResultsThe new over-the-top subscapularis repair significantly increased the abduction moment arm lengths in the superior, middle, and inferior subscapularis components compared with the standard repair to the lesser tuberosity at all levels of glenohumeral abduction and for all 3 RSA designs. Repair of the upper two-thirds of the subscapularis to the new location was an abductor at a much lower level of abduction compared with the native subscapularis repair.ConclusionBy repairing the upper subscapularis tendon above the center of rotation (over-the-top repair) in an RSA muscle model, the subscapularis has an improved movement arm and functions as an abductor through a greater range of motion that may result in clinically increased muscle efficiency and improved strength.