most accurately predicts experimental observations. The combination of biochemical modeling and precise experimental manipulation and quantification provides unique insights into the relationship between the density of increased local concentrations of Nck and resulting localized actin polymerization. (Supported by NIH grants P41 RR013186 and U54 RR022232)
Calcitriol is the active form of Vitamin D 3. Epidemiological data show that women with Vitamin D deficiency at the time of breast cancer diagnosis are 94% more likely to experience cancer spread and 73% more likely to die over the next 10 years, compared to women with adequate Vitamin D levels. Since vitamin D deficiency is especially common in African American and obese women, this observation may partially explain the relatively poor clinical outcome experienced by these patients [2]. Although current treatments for IBC
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