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Abbreviations: CHD, coronary heart disease; FTND, Fagerström Test for Nicotine Dependence; NRT, nicotine replacement therapy.A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances. Intervention Study for Smoking Cessation in Diabetic PatientsA randomized controlled trial in both clinical and primary care settingsOBJECTIVE -To evaluate the effectiveness of a nurse-managed smoking cessation intervention in diabetic patients. RESEARCH DESIGN AND METHODS -This randomized controlled clinical trialinvolved 280 diabetic smokers (age range 17-84 years) who were randomized either into control (n = 133) or intervention (n = 147) groups at 12 primary care centers and 2 hospitals located in Navarre, Spain. The intervention consisted of a 40-min nurse visit that included counseling, education, and contracting information (a negotiated cessation date). The followup consisted of telephone calls, letters, and visits. The control group received the usual care for diabetic smokers. Baseline and 6-month follow-up measurements included smoking status (self-reported cessation was verified by urine cotinine concentrations), mean number of cigarettes smoked per day, and stage of change.RESULTS -At the 6-month follow-up, the smoking cessation incidence was 17.0% in the intervention group compared with 2.3% in the usual care group, which was a 14.7% difference (95% CI 8.2-21.3%). Among participants who continued smoking, a significant reduction was evident in the average cigarette consumption at the 6-month follow-up. The mean number of cigarettes per day decreased from 20.0 at baseline to 15.5 at 6 months for the experimental group versus from 19.7 to 18.1 for the control group (P Ͻ 0.01).CONCLUSIONS -A structured intervention managed by a single nurse was shown to be effective in changing the smoking behavior of diabetic patients.

Mitogenic stimulation of lymphocytes involves alkalinization of intracellular pH (pH i ). Subsequent pH i regulation may involve HCOAdditional supporting information may be found in the online version of this article at the publisher's web-site

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