Highlights d Tissue recovers robust migration in the continued presence of a chemokine flood d Chemokine-driven phosphorylation triggers recycling of the scavenger receptor Cxcr7b d Phospho-deficient Cxcr7b mediates migration but not adaption to elevated chemokine levels d Adaptation to chemokine changes outsourced from the guidance receptor Cxcr4 to Cxcr7b
Development and evolution are dynamical processes under the continuous control of organismic and environmental factors. Generic physical processes, associated with biological materials and certain genes or molecules, provide a morphological template for the evolution and development of organism forms. Generic dynamical behaviors, associated with recurring network motifs, provide a temporal template for the regulation and coordination of biological processes. The role of generic physical processes and their associated molecules in development is the topic of the dynamical patterning module (DPM) framework. The role of generic dynamical behaviors in biological regulation is studied via the identification of the associated network motifs (NMs). We propose a joint DPM–NM perspective on the emergence and regulation of multicellularity focusing on a multicellular aggregative bacterium, Myxococcus xanthus. Understanding M. xanthus development as a dynamical process embedded in a physical substrate provides novel insights into the interaction between developmental regulatory networks and generic physical processes in the evolutionary transition to multicellularity.
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