Resumo: Ao pensar as relações entre arte e educação a partir da linguagem, abordamos o espaço ocupado pela arte no universo da educação dentro e fora da escola, focando nas práticas cotidianas, no espaço ordinário outorgado ou não como espaço de arte. As interferências produzidas nos cotidianos e nos espaços disciplinares contemplados às artes, entendidas como produção estética e poética e imbuídas dos sentidos de desejo e de presença, são abordadas como práticas nas quais ocorre, por meio da criação e da fruição estéticas, a tessitura de conhecimentos outros, em direção à ecologia de saberes, compreendidas como potente meio para a formação humana democratizante, (re)existência à colonialidade do saber/fazer/ser.

The P38 MAPK protein is mainly involved in the synthesis of the proinflammatory cytokines IL1 and TNF-alpha and is important in the maintenance and amplification of the inflammatory process. Therefore, this protein presents high potential as a pharmacological target in the search for new treatments for inflammatory diseases. In silico approach has been of great importance to develop quick and inexpensive target identification and way to discover new bioactive molecules. This study used a computer ligand-docking method to screen the compounds from the Bahia semiarid region in silico for their ability to inhibit p38 MAPK activity. The protein crystallographic structure of the p38 MAPK was obtained from the Macromolecular Protein Data Bank. Northeast semiarid molecules were obtained from the ZINC database. The database was screened and a set of 233 molecules were selected as candidates using filtering based on parameters of the rule of Lipinski and Verber. The docking was carried out using the program Autodock Vina in its default configuration. The compound with ZINC databank code: 91596862 was found the most promising compound acoording to their binding free energy value obtained in the docking experiments (11,1 Kcal.mol-1) Intermolecular interactions analysis suggested that Van der Waals interactions are crucial to the ZINC molecule 69481892 in the active site of the p38 MAPK protein. Data resulting from all dockings are significant, although it has low accuracy. Thus, the hypothetical results of these in silico studies should be confirmed by in vitro and/or in vivo tests.

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The glucocorticoid receptor regulates the anti-inflammatory response, and prevents transcription of anti-inflammatory substances such as nuclear factor kB and lipocortin-1, IL-2, IL-6, TNF and prostaglandins. Thus, a search for new molecules with potential interaction with the glucocorticoid receptor is an interesting strategy for the treatment of inflammatory diseases. Virtual screening has proven to be a viable tool for discovering new products at lower cost and practicality. Thus, the aim of this study is to identify and evaluate brazilian semiarid compounds with anti-inflammatory potential with glucocorticoid receptor action through molecular coupling. Protein selection was performed by searching the 3D structure database, Protein Data Bank. A total of 382 semi-arid molecules available in the ZINC database of State University of Feira de Santana (UEFS) were used. Molecular docking was performed using Autodock Vina and as interaction clouds analyzed by the Discovery Studio Visualizer program. Mometasone furoate shows a binding energy of -12.7 Kcal.mol-1. A ZINC 69481862 molecule fits Lipinski and Veber rules, however, the best interaction was the ZINC 69482012 molecule, evidenced by the binding energy -11.2 Kcal.mol-1. Analyses of intermolecular interactions have shown that Van der Waals interactions and electrostatic bonds are crucial for the binding of the molecule at the receptor's active site. It is necessary to test in vitro to verify the viability and toxicity of the potential drug.

Filamentous fungi are eukaryotic organisms with several industrial and pharmaceutical applications. Polysaccharides are the principal components of cell walls from Fungi and other organisms like diatoms, and have been reported in the industrial and medical fields as products with a huge number of different biological activities and applications. The objectives of this narrative review were to assess the characterization methods and and biological activities of polysaccharides extracted from the filamentous fungal cell wall. Glucans, chitin and galactomannans are the most common polysaccharide often found in the cell walls of fungi. These polysaccharides can contain different glycosidic linkage either an α or β-configuration and at various positions, such as (1-3,1-4, 1-6), as well as several molecular sizes. This leads to an almost limitless diversity in their structure and biological activity. There are many methods for polysaccharides characterization, among them; the methods commonly used involve Infrared Spectrometry (FT-IR), Nuclear Magnetic Resonance Spectroscopy (MRS), and gas chromatography-mass spectrometry (CG-MS). Typically, cell wall polysaccharides from filamentous fungi have been shown to possess complex, important and multifaceted biological activities including mainly antioxidant, anti-inflammatory, immunomodulatory, antinociceptive, antitumor and hypoglycemic activities. Due to the large number of filamentous fungi genus and species capable of producing useful polysaccharides, perform scientific researches, and produce novel scientific knowledge and information are particularly interesting in order to identify polysaccharides with potential biological activity and that can be used for medicinal purposes.

RESUMO -Pesquisa em Performance: encontro, palavra e corpo -Este é um artigoencontro, um artigo-diálogo entre dois professores-pesquisadores e dois artistas dedicados à performance e que também têm a universidade como espaço de experimentação: Sara Panamby e Filipe Espindola. Neste encontro, tentamos traduzir em palavras os afetosensinamentos das experiências limites do casal. A pergunta sobre o que é a performance, e especificamente as experiências criadas pelos performers conduziram-nos a exemplos das dores e amarras que condicionam nossos corpos, violências biopolíticas em algumas das suas dimensões, mas também às forças, às dores de libertação e às delícias que podemos produzir para escapar à jaula afetiva e sensório-motora que nos coloniza. Descolonização dos corpos de toda a violência, mas também intercolonização que fez de todos nós outros ali: aprendizado que só pôde acontecer por uma certa violência, espanto e maravilhamento. Palavras-chave: Performance. Palavra. Corpo. Sara Panamby. Filipe Espindola. ABSTRACT -Research on Performance: meeting, word and body -This is a meetingarticle, a dialogue-article between two teachers-searchers and two artists dedicated to the performance and who also have the university as a space of experimentation: Sara Panamby and Filipe Espindola. In this meeting we tried to translate in words the teaching/affections of the couple's experiences. The question about what the performance is, and specifically the experiences created by the performers, led us to examples of the pains and moorings which condition our bodies, bio-political violences in some of their dimensions, but also to the strengths, to the pains of freedom and to the delights that we can produce to escape from the affective and sensory-motor cage that colonizes us. Decolonization of the bodies from all the violence, but also cross-colonization that makes all of us others there: a learning that could only happen because of a certain violence, astonishment, and amazement. Keywords: Performance. Word. Body. Sara Panamby. Filipe Espindola. RÉSUMÉ -Recherche sur la Performance: rencontre, parole et corps -Il s'agit d'un article-rencontre, un article-dialogue entre deux professeurs/chercheurs et deux artistes dédiés à la performance et qui ont aussi l'université comme un lieu d'expérimentation: Sara Panamby et Filipe Espindola. Lors de cette rencontre, nous avons essayé de mettre en mots les affects-apprentissages des expériences limites du couple. La question sur ce qu'est la performance, et en particulier les expériences qu'ils ont créées, nous ont conduits à des exemples des maux et des chaînes qui conditionnent nos corps, les violences biopolitiques dans certaines de ses dimensions, mais, aussi aux forces, aux douleurs de libération et aux plaisirs que nous pouvons produire pour échapper à la cage affective et sensorimotrice qui nous colonise. La décolonisation des corps de toutes les violences, mais aussi l'intercolonisation qui nous a fait devenir les autres là: un apprentissage qui ne peut arriver que par une ...

-The Cutthroat Colonel's Horn: an aesthetic-political action -This article considers an aesthetic-political action: namely, an intervention of activists directed at the painted portrait of a bloodthirsty historical figure. Considering the inexorably aesthetic dimension of politics, this work articulates the constitution of socius and ethos according to Deleuze and Guattari with a singular reading of the concept of Duchamp's readymade. Thus, the article arrives at the conception of an effect of art. This theoretical base allows us to consider the specific political action that serves as the theme of the text as an example of the effect of art. This consideration occurs both within the context of an identification between artistic/cultural patrimony and the State, but also in the aestheticpolitical resistances of a city submitted to the violent processes of gentrification. RESUMO -O Chifre do Coronel Corta-Gargantas: uma ação estético-política -Este artigo analisa uma ação estético-política: uma intervenção feita por ativistas na pintura do retrato de um sanguinário personagem histórico. Considerando a dimensão inexoravelmente estética da política, articularemos a constituição do socius e do ethos, segundo Deleuze e Guattari, com uma singular leitura do conceito de ready made em Duchamp; chegaremos assim à concepção de efeito de arte. Tal base teórica nos permitirá pensar a ação política tema do texto como exemplo de efeito de arte, num contexto de identificação entre patrimônio artístico/cultural e Estado, mas também de resistências estético-políticas numa cidade submetida a violentos processos de gentrificação. Palavras-chave: Ação Estético-Política. Socius e Ethos. Efeito de Arte. Cidade. Estéticas do Poder e da Resistência.

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