Physical effects of growth hormone treatment in children with Prader-Willi syndrome. Acta Padiatr 1999; Suppl 433: 1124. Stockholm. ISSNA randomized, controlled study of 54 children (age, 4-16 years) with Prader-Willi syndrome was conducted to assess the potential beneficial effects of growth hormone (GH) treatment. After observation for 6 months, the children were randomized to receive GH at a dose of 3 IU/m2/day (1 mg/m2/day) (n = 35) or no intervention (n = 19). The effects of GH treatment on linear growth, body composition, muscle strength, pulmonary function and resting energy expenditure were assessed. The levels of GH secreted in response to clonidine stimulation were universally low, and mean (.t SD) insulin-like growth factor I SDS was -1.2 f 0.8 pretreatment. In children treated for 1 year, mean height velocity SDS significantly increased from -1.0 f 2.5 to 4.6 f 2.9
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.