An unknown impurity in the fermentation-based drug substance lovastatin at 0.52 RRT was observed invariably in all batches when analyzed by HPLC as per the PhEur monograph. This impurity was isolated from the impurity-enriched sample using reversed-phase preparative HPLC and characterized by using spectroscopic (PMR, CMR, MASS, and UV) techniques as the structurally-related compound Monacolin-X, having the molecular formula C24H34O6 and the chemical name 2-methyl-3-oxobutanoic acid 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester.
Deluge of June 2013 is the worst disaster faced by the nation in recent times. Changing rainfall pattern in the previous some years has made heavy localized precipitation all the more common in Uttarakhand and the same is a cause of concern for the state government, meteorologists and other researchers. These incidences cause enormous loss of human lives, property, infrastructures and natural resources. Moreover rainfall in the study area is highly variable even over short distances. Dissected topography and tectonically active nature of the area further promote mass movement and slope instability. Increased indiscriminate anthropogenic intervention along the river banks, on glacial sediments, thick colluviums zones and river borne materials on moderate to steep slope, has often resulted in devastation in the area. The study highlights causes of slope instability together with the geomorphic changes and suggestions for future developmental initiatives within the district.
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