No abstract

No abstract

No abstract

No abstract

A clonal cell line derived from a mouse neoplasm is described which shares many properties with smooth muscle . The cells have electrically excitable membranes capable of generating overshooting action potentials, and they contract both spontaneously and with electrical stimulation . They respond to the iontophoretic application of acetylcholine with a depolarizing response, and to norepinephrine with a hyperpolarizing response . Electron microscopy reveals that the cells have a morphology similar in many, but not all, respects to that of smooth muscle cells in vivo . The cells secrete soluble collagen-like molecules in addition to several proteins of undefined function . Finally, there is an increase in the specific activities of creatine phosphokinase and myokinase associated with increased cell density and the cessation of cell division.