Останнім часом частота гострих судинних подій, пов'язаних із тромбозом, особливо у хворих на ішемічну хворобу серця (ІХС), невпинно зростає. Тому, для профілактики шляхом впливу на основні ланки патогенезу ІХС широко застосовують антитромбоцитарні засоби (профілактика агрегації тромбоцитів і пристінкового тромбоутворення): ацетилсаліцилову кислоту (АСК), тієнопіридини (клопідогрель, тікагрелор, тиклопідин) та ін. У дослідженні узагальнено сучасні підходи до антитромбоцитарної терапії з врахуванням ступеню агрегаційної активності тромбоцитів та визначення чутливості до антитромбоцитарних препаратів Ключові слова: ішемічна хвороба серця, стенокардія, агрегація тромбоцитів, антитромбоцитарна терапія, резистентність до антитромбоцитарних засобів
Mutation C807 in the ITGA2 gene is associated with the risk of early myocardial infarction, ischemic stroke, embolism, thrombosis after angioplasty and stenting of coronary arteries.
Aim
To study the relationship between ITGA2 gene polymorphism and increased risk of CAD in patients with hypertension and hypercholesterolemia
Materials and methods
72 patients were included. Study involved patients with ACS, which developed on the background of hypertension, 32 patients also had coronary angiography and stenting. We used analysis of spontaneous and induced platelet aggregation, polymorphism of C807T of the ITGA2 gene was determined by polymerase chain reaction.
Results
At 82.5% of patients with ACS genotype ITGA 2 C/T was prevalent – 40.3%, T/T – 31.9%. Aggregation capability research in the studied groups has shown that patients of all groups had their degree of spontaneous aggregation significantly exceeding limits of control. Wherein, the highest indices were recorded in the T/T genotype group, which exceeded reference values by 3,02 times. AA-induced aggregation in the group of patients with T/T genotype exceeded indexes of the C/C group by 17.3%, while C/T group's rates-by 16.5% (p<0.05 in both cases). Studying the degree of collagen-induced aggregation, it was noted that the highest rates were recorded in T/T genotype group – 1.68 times higher than control group.
Conclusion
It is found that T allele of ITGA2 carrier is typical for 72.1% of patients with acute coronary syndrome and combined with spontaneous acceleration of platelet aggregation and increases sensitivity of platelets to ADP and collagen. Results allow us to consider the carrier of the T-allele as a marker of predisposition to thrombophilia.
FUNDunding Acknowledgement
Type of funding sources: None.
Thyroid diseases are widespread and are the most common endocrine pathology, especially in regions with iodine deficiency in the environment. Thyroid dysfunction is diagnosed in 5-10 % of the population, more often in women and in the age group over 60 years. With increasing age, the occurrence of comorbid diseases in patients is increasing significantly. Among them, the first place belongs to the pathology of the cardiovascular system.One of the factors is endothelial dysfunction, which is one of the predictors of morphological changes in the vascular wall in many chronic diseases, in particular, atherosclerosis, arterial hypertension, thyroid diseases, and others.
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