Pyrazole and its derivatives are one of the interesting heterocyclic compounds among the other because it has tremendous important bio-medical applications such as anticancer, antimalarial, antimicrobial, antifungal, antitubercular and antihelishmanial. Synthesis of pyrazoles by synthetic route requires harsh reaction conditions such as organic solvent, high temperature, require large time that consume more energy which increase final cost of the synthesis of pyrazoles. Therefore researchers be aware about synthesis and give more attention towards to develop a greener as well as economically favorable method for synthesis of pyrazoles such as microwave irradiation, ultra-sonication assisted, reaction at room temperature, solvent and catalyst free and use of universal solvent that is aqueous medium these techniques are environmentally friendly as well as cost effective. Therefore, these review highlights the greener methodologies for the synthesis of pyrazoles, which are good alternative for synthetic methods that sustains green principles.
In these environmentally conscious days there is need to use eco-friendly greener technologies, such as solvent free, microwave, ultrasound and use of room temperature. Here report an efficient and green protocol for the synthesis of 5-aminopyrazole-4-carbonitrile from three component condensation of phenyl hydrazine, aldehyde, and malononitrile using NaPTS as catalyst in aqueous medium. Use of water has emerged as a versatile solvent for organic reaction; it is readily available, inexpensive, environmentally benign, neutral and natural solvent. Multicomponent reactions in water are of outstanding value in organic synthesis and green chemistry. The significant features of this article are short reaction time, provide excellent yield, removal of toxic solvent and use of water as green solvent.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.