role of curcumin, the present study was designed to investigate if the use of this dietary spice would be effective in reducing incidence of CVD in HFD-fed male rats. Materials and Methods Experimental animals This study was performed on male albino rats of Wistar strain, initially weighing 175 ± 5 g. Rats were obtained from the Institute of Ophthalmic Disease Research, Cairo. Egypt. They were housed in stainless steel cages at a well ventilated animal house. Rats were permitted adequate standard diet and given water ad libitum for one week of acclimatization period prior to the experimental work. Chemicals Curcumin [1.7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5dione] the active constituent of the dietary spice turmeric was purchased from El-gomhoriaCompany for Chemicals, Mansoura, Egypt. All other reagents were of analytical grade and were purchased from local standard suppliers. Research design After one week of acclimatization, rats were randomly divided into five equal groups. The first was considered as control group, in which rats received normal laboratory diet (NLD) without supplementation. The second group was fed NLD and received 5% DMSO orally as
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