Colorectal cancer (CRC) is the second most deadly cancer. Global incidence and mortality are likely to be increased in the coming decades. Although the deaths associated with CRC are very high in high-income countries, the incidence and fatalities related to CRC are growing in developing countries too. CRC detected early is entirely curable by surgery and subsequent medications. However, the recurrence rate is high, and cancer drug resistance increases the treatment failure rate. Access to early diagnosis and treatment of CRC for survival is somewhat possible in developed countries. However, these facilities are rarely available in developing countries. Highlighting the current status of CRC, its development, risk factors, and management is crucial in creating public awareness. Therefore, in this review, we have comprehensively discussed the current global epidemiology, drug resistance, challenges, risk factors, and preventive and treatment strategies of CRC. Additionally, there is a brief discussion on the CRC development pathways and recommendations for preventing and treating CRC.
Acne, also known as acne vulgaris (AV), is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin. It is characterized by blackheads or whiteheads, pimples, oily skin, and possible scarring. An intact stratum corneum and barrier, normal natural moisturizing factor and hyaluronic acid levels, normal Aquaporin-3 (AQP3) expression (localized at the basal lateral membranes of collecting duct cells in the kidney), and balanced sebum secretion are qualities of the skin that fall in the middle of the oily–dry spectrum. Patients rarely, if ever, complain about reduced sebum production, but elevated sebum production, yielding oily skin that can be a precursor to acne, is a common complaint. Several factors are known to influence sebum production. AV is mostly triggered by Propionibacterium acnes in adolescence, under the influence of normal circulating dehydroepiandrosterone (DHEA). It is a very common skin disorder which can present with inflammatory and noninflammatory lesions chiefly on the face but can also occur on the upper arms, trunk, and back. Age, in particular, has a significant and well-known impact, as sebum levels are usually low in childhood, rise in the middle-to-late teen years, and remain stable into the seventh and eighth decades until endogenous androgen synthesis dwindles. Sebum, the oily secretion of the sebaceous glands containing wax esters, sterol esters, cholesterol, di- and triglycerides, and squalene, imparts an oily quality to the skin and is well known to play an important role in acne development. Acne can’t be prevented or cured, but it can be treated effectively. The pimples and bumps heal slowly, and when one begins to go away, others seem to crop up. Depending on its severity, acne can cause emotional distress and scar the skin. Acne may cause scarring of the skin, but generally causes no long-term health problems. In self-body image, some parts of the body including face play an important role. Existence of even a minor lesion in this part may be unpleasant for the patient and seems large. This image can cause mental disorders including depression and anxiety, low self-esteem, and decrease in social relationships. However, high levels of anxiety and depression in patients with facial acne are not related to oxidative stress, according to a study published online in the Journal of Cosmetic Dermatology
<p>Patient satisfaction is a useful measure for providing a quality benchmark for healthcare services. Concern about the quality of healthcare services in Bangladesh has led to a loss of confidence in healthcare providers, low use of public health facilities and increased outflows of patients from Bangladesh to hospitals abroad. The key obstacles to access to health services are insufficient infrastructure and poor quality of existing facilities, lack of medical equipment, scarcity of doctors due to high patient load, long distance to the facilities and long waiting times until facilities have been reached, very short appointment hours, lack of empathy of health professionals, their generally callous and casual attitude, aggressive pursuit of monetary gains, poor levels of competence and, occasionally, disregard for the suffering that patients endure without being able to voice their concerns-all of these service failures are reported frequently in the print media. Such failures can play a powerful role in shaping patients’ negative attitudes and dissatisfaction with healthcare service providers and healthcare itself.</p>
Patient's satisfaction is a useful measure to provide an indicator of quality in healthcare services. Concern over the quality of healthcare services in Bangladesh has led to loss of faith in healthcare providers, low utilization of public health facilities, and increasing outflow of Bangladeshi patients to hospitals in abroad. The main barriers to accessing health services are inadequate services and poor quality of existing facilities, shortage of medicine supplies, busyness of doctors due to high patient load, long travel distance to facilities, and long waiting times once facilities were reached, very short consultation time, lack of empathy of the health professionals, their generally callous and casual attitude, aggressive pursuit of monetary gains, poor levels of competence and, occasionally, disregard for the suffering that patients endure without being able to voice their concernsall of these service failures are reported frequently in the print media. Such failures can play a powerful role in shaping patients' negative attitudes and dissatisfaction with healthcare service providers and healthcare itself.
Plants are unrivaled in the common world in both the number and unpredictability of secondary metabolites they produce, and the pervasive phenylpropanoids and the heredity explicit glucosinolates speak to two such vast and artificially various gatherings. Advances in genome-empowered natural chemistry and metabolomic innovations have incredibly expanded the comprehension of their metabolic systems in assorted plant species. There additionally has been some advancement in explaining the quality administrative systems that are critical to their combination, gathering and capacity. Secondary metabolites have essential defense and flagging jobs, and they add to the general quality of creating and aging natural products. Particularly, light conditions and temperature are exhibited to have an unmistakable job on the organization of phenolic compounds. The present survey centers around the examinations on components related with the guideline of key secondary metabolites, mostly phenolic compounds, in different plants. are a helpful cluster of normal items as well as an essential piece of plant defense framework against pathogenic assaults and environmental stresses. With astounding biological exercises, plant SMs are progressively utilized as drug fixings and nourishment added substances for remedial, fragrant and culinary purposes. Different hereditary, ontogenic, morphogenetic and environmental components can impact the biosynthesis and aggregation of SMs. As indicated by the writing reports, for instance, SMs gathering is unequivocally reliant on an assortment of environmental factors, for example, light, temperature, soil water, soil richness and saltiness, and for most plants, an adjustment in an individual factor may modify the substance of SMs regardless of whether different elements stay steady. Here, we survey with accentuation how every one of single elements to influence the collection of plant secondary metabolites, and lead a relative examination of applicable normal items in the stressed and unstressed plants. Hopefully, this narrative survey will diagram a general picture of environmental elements in charge of change in plant SMs, give a handy method to get reliable quality and high amount of bioactive compounds in vegetation, and present a few proposals for future innovative work.
Breakfast, the first meal of the day, is considered the most important meal throughout the day. As nutritionist Adelle Davis famously put it back in the 1960s: “Eat breakfast like a king, lunch like a prince and dinner like a pauper”. Breakfast is most commonly skipped meal more than lunch and dinner specifically in the young adult in the university study period and those who wake up late. Lack of time is the main reason behind skipping meals, in general, lack of appetite, inability to cook, fasting/religion, and not being hungry. Many people are used to be in a hurry for job, business, children’s’ school in the morning where a filled stomach may prevent them to walk a long way. It is obvious that the irregular omission of breakfast may be effective in energy intake reduction over the next 24 hours and in this day, exercise performance may be compromised. There is no evidence that breakfast skipping reduces overeating or prevent weight gain. Some people argue that breakfast and good health is a marketing strategy by breakfast companies.
Environmental pollution and food contamination are as old as the civilization itself. It is the result of the improvement of civilization, over usage of nature, industrialization and in certainty a cost for the advancement. It is exceedingly conspicuous in Dhaka city. Air pollution is chiefly because of the vehicle emanation, modern release and consuming of non-renewable energy source. The water asset of Dhaka turns into a noteworthy wellbeing danger because of arsenic contamination, insufficient family unit/modern/restorative waste transfer and mechanical emanating the executives. Food contamination originated from the commercialism of specialists who are doing this purposely to augment benefit. Fundamental advances are to be taken to secure nature for our own reality. This paper uncovers compound pollution and contamination issues of Dhaka city, the capital of Bangladesh. Brief review of chemical induced pollution and contamination, their consequences and control. Healthcare providers/Policy makers have a major role play to the concerned field. Comprehensive literature search followed by consulting healthcare professionals about environmental pollution and food contamination. Hospital, clinic and company personnel, newspaper journalists, NGO workers given their valuable suggestions and asked help for necessary books, journal, newsletters. A few western magazine and newspapers also observed to get the necessary concern. Projections were based on public life pattern, their food habits, pollution and contamination sources, waste disposal features of urban life as well as industry and hospital waste disposals. Pollution and adulteration are the most notorious enemy of mankind. Civilization has its own drawback that even causing destruction of itself. Very few people raised voice on this but crippled by the facts of commercialism. The scope of this article is limited to chemical pollution of air and water, medical or household waste products and food contaminants and adulterants. A few discussions based on real life experience and recent studies or reports from various journals and news articles are summarized here. Both general people and the old system, are responsible for this unlivable condition of Dhaka city. The population is not the sole for this instance. A sense of poor rules and regulation is always found everywhere. Negligence is becoming a wide spread disease contaminating illiterate to well educated, all kind of people. Many articles and documents found in concerned area of research, but the scope of this research is on its focus point chemical hazards and burdens of Dhaka city. Still the most important aspect is covered, but fact is less amount of recent data found in few areas. The language of this article is too simple to understand by people with simple literacy. Pharmacists, doctors, nurses, hospital authorities, public representatives, policy makers and regulatory authorities have to acquire much from this article. Any article or research is based on the think doing good for mankind, at least goin...
Psychiatric disorders are one of the major causes of global burden of diseases. Stigma remains a major impediment in the delivery of mental healthcare. It has been found across various studies that attitudes of doctors of other specialties and other healthcare professionals also contribute to stigma due to their lack of knowledge and awareness about psychiatry and mental health problems. The number of mental health professionals remains abysmally low. Community pharmacists are accessible, knowledgeable, and capable of providing mental health promotion and care in communities. This may not be a role that is recognized by the public, and men in particular. However, psychotherapy paired with medication is the most effective way to promote recovery. Examples include: Cognitive Behavioral Therapy, Exposure Therapy, Dialectical Behavior Therapy, etc. Pharmacists can play a key role by providing mental health medication management support to improve access and address patients' mental health needs.
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