Background: Delivery bleeding is still a major catastrophe that facing most of obstetricians, leading to global maternal exhaustion and fatality. So estimation of the blood loss and the changes occurring during the procedure are important in the management of the bleeding. Aim of the study: : Comparing loss of blood during Cesarean Delivery, Intra and post-operative in parturients, injected by Oxytocin versus Tranexamic acid with Ethamsylate. Patients and Methods: Blinded randomized controlled trial, whereas 200 of Gravid women shared and equally distributed to double collections, each collection includes 100 of women and Each of them is injected with Syntocinon 5 IU infusion on 500 cc saline 0.9%, at rate of 100cm/hour Or Tranexamic acid with Ethamsylate, 5 to 10 min IV slowly before the abdominal delivery, with evaluation of the bleeding amount.Results: Blood loss amount, participants requiring for blood transfer OR more intervention, were minimal in the tranexamic acid and ethamsylate collection than in the oxytocin collection. Moreover the results of hemoglobin and hematocrit postoperatively were elevated in the participants who injected by both tranexamic acid and ethamsylate comparing with the participants who injected by the Syntocinon. Conclusion:The Evaluated variables with the positive and negative results of the research medications, demonstrated the following: Both Tranexamic acid and Ethamsylate could be effective than Oxytocin in minimizing the demand for blood transfer, with the stability of both hematologic profile and the hemodynamics. And both too, appear to be safe and efficient option in the management of the abdominal delivery.
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