Highlights In Abu Dhabi, sRAGE levels were significantly lower in T2D vs. control subjects. There were no significant differences in esRAGE levels in T2D vs. control subjects. Levels of sRAGE in T2D vs. controls were not significant after correction for eGFR. In T2D subjects ≥age 70 years, trends to lower eGFR were observed vs. controls. Renal function may significantly affect sRAGE levels in Abu Dhabi Emirati.

No abstract

An increasing number of failed transplant patients returning to dialysis (FTRD) have been observed with reported worse survival compared to transplant-naive dialysis (TxN) patients. This study aimed to assess outcomes of FTRD vs. matched TxN controls in a Gulf region multi-center trial of 800 HD patients. Similar mortality was seen, likely due to earlier start and better HD adequacy in FTRD. Younger age, less diabetes and living donor transplantation in majority with 27% graft nephrectomy (Nx) might also confer benefits. Subgroup analysis of Nx patients showed more hospitalizations and prior rejection episodes with lower graft survival. The deaths, however, occurred only in nonNx group and are likely explained by older age, longer duration on HD, more prevalence of diabetes and CAD. FTRD showed similar survival to TxN. Early intensive HD might account for the benefit. Whether Nx confers advantage is unclear because of the small sample size.