Four ports laparoscopic cholecystectomy (LC) has been the standard for treatment of the symptomatic cholelithiasis. Herein, the experience of two-ports LC regarding its safety and feasibility was given. This study was conducted in Theodor Bilharz Research Institute (TBRI) in the period from November 2017 till April 2018, as a prospective randomized study including one hundred patients with chronic calcular cholecystitis, which were divided into two equal groups. The study compared between group A (GA) which underwent four ports LC and group B (GB) which underwent two ports LC.The results showed that in GA, no cases were converted to open cholecystectomy. But, in GB only two patients converted to three-port laparoscopic cholecystectomy. There were no intraoperative complications encountered in any patient in both groups. In GA, operative time ranged between 28-62 minutes (mean±44.57) while in GB, operative time ranged between 39-134 minutes (mean±59.93); with hospital stay of three days in both groups. The pain score showed statistically significant differences regarding port-site pain (P value = 0.040). Significant lower analgesic demands were recorded in the 2 ports group. Scar satisfaction showed a marked statistically significant differences regarding the aesthetic results between the two groups (P value = 0.0319).
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