Methomyl (MET) [S-methyl N-(methylcarbamoyloxy) thioacetimidate ]C 5 H 10 N 2 O 2 S] is considered as one of the most important carbamate (oximes) pesticides that is extensively utilized around the world. Carbamate compounds were found to create an alteration in biochemical parameters and affect the oxidative status of the body through producing free radicals. Herbal medicines derived from plant extracts are useful in treatment of a variety of clinical disease, they are considered as natural antioxidants that have a protective role against toxicities. The purpose of the present investigation was to assess the ability of green tea extract (GTE) to protect kidney against methomyl induced toxicity in experimental animals. The insecticide caused significant elevation in urea, creatinine, NF-κB and malondialdehyde levels, and marked decrease in the levels of superoxide dismutase, reduced glutatione and glutathione-S-transferase. Alterations in these biochemical markers occurred were referred to kidney damage and the oxidative stress induced by MET. Co-administration of GTE of higher concentration (1.5%) in combination with MET brought the tested biochemical parameters to their normal levels. The study introduced novel findings regarding to the protective effect of GTE and their mixture against MET-induced toxicity in female albino mice.