1 The kinetics of digoxin have been investigated in healthy volunteers using an isotopic tracer technique. 2 A three compartment open kinetic model has been proposed as the simplest model consistent with the plasma, urinary and faecal data obtained. 3 The renal clearance of digoxin (mean ± s.d.) was found to be 119 ± 10 ml/min, which did not differ significantly from the glomerular filtration rate (1 10 ± 14 ml/min). 4 Digoxin extra-renal clearance (mean ± s.d.) was found to be 47 ± 7 ml/min. 5 The model predicts that the tissue concentration attained after four 0.25 mg oral doses spread over 24 h can be achieved within a period of 4 h following a single oral loading dose of 1 mg.6 Maintenance doses can be derived from a simple formula based on the glomerular filtration rate, extra-renal clearance and bioavailability of the digoxin preparation used.
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