The development of the pathology of individual organs and systems undoubtedly depends on adverse environmental factors. The heavy metal imbalance affects the health of the population and may lead to unpredictable consequences. Тhe hormones of the intermediate part of the pituitary gland are one of the key places in regulating and maintaining the basic functions of the organism. Тhe question of the influence on the intermediate part of the pituitary gland of the combination of heavy metal salts remains relevant and insufficiently studied. In order to study the morph functional rearrangements of the structural components of the intermediate pituitary gland of sexually mature female rats, an experiment was conducted on 12 animals weighing 250–300 g, aged 7–8 months. The animals of the experimental group consumed normal drinking water saturated with a combination of salts of heavy metals for 60 days. Morphometric, statistical, immunohistochemically, biochemical, and histological methods were used. Significant thickening and edema of the inter trabecular connective tissue septum, depletion of capillaries and morphological rearranging part of the troposites, mainly their nuclear apparatus (condensation of chromatin and its marginal location, initial stages of necrobiotic changes), is manifested. Prolonged intake of sexually mature female rats of heavy metal salts leads to morph functional rearrangements of all structural components of the intermediate lobe of the pituitary gland. The above morph functional changes are of a non-specific polymorphic nature and are characteristic of the stage of increased resistance of the general adaptation syndrome.
The purpose of this study was to investigate the mechanism of folliculogenesis in the thyroid gland under the influence on the organism combinations of salts of heavy metals. The study was conducted on 24 white laboratory rats. By mathematical simulation showed that in the wall of the follicle ellipsoid greater tension arises from the longitudinal section of an ellipse and a cross-sectional voltage decreases. Draws attention to the important role intraluminal colloidal pressure in the process of folliculogenesis. The paper makes the assumption that the difference between peripheral and central folliculogenesis arises from the different values intraluminal pressure, which in turn is derived from different functional activity of the follicular epithelium.
The article presents the results of the study on morphological rearrangements of structural changes in the rat pineal gland under the influence of heavy metal salts and correction with L-tocopherol during 30 days. General morphological and statistical research methods were used (histological, morphometric and statistic methods). The protective effect of L-tocopherol caused in the pineal gland a number of compensatory-adaptive processes aimed at neutralizing the stressor's impact on the organ. The 30days protective period of L-tocopherol is insufficient to completely neutralize the impact of heavy metals on the organ: the glial response was activated, vascular area increased, vascular wall permeability was impaired, edema was formed and the connective tissue component growth was taking place, indicating dysfunctional reorganization in the gland's secretory activity. The above morphological changes negatively affected the processes of hormones evacuation into the blood, the course of the general adaptation syndrome and the homeostasis restoration in the organ.
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