School climate is a topic of increasing importance internationally. The current study investigated the established measurement invariance of an eight-factor school climate scale using a multi-national sample of secondary students. School climate factor means across 14 international groups were compared and findings on the association between school climate factors and mental health were also investigated. Findings from this study illustrate several
Introduction. Chronic thromboembolic pulmonary hypertension (CTEPH) is one of the most severe complications of pulmonary embolism (PE), characterized by poor prognosis and insuffcient effectiveness of standard treatment approaches. A small number of representative models of CTEPH make it diffcult to conduct preclinical studies of promising pharmacological substances.Objective – development and validation of the experimental model of CTEPH in rats by embolization of the distal branches of the pulmonary artery with biodegradable microspheres.Material and methods. Male Wistar rats were used for the experiments. Biodegradable microspheres (MS) based on sodium alginate and autologous blood clots (AT) were used as embolizing particles. The animals were divided into groups: control: saline solution was injected 4 times with an interval of 8 days into the tail vein; AT: according to the above protocol, 50 μL of AT was injected; MS was administered intravenously in a volume of 50 μl of MS according to two protocols: MS4: 4 times with an interval of 8 days; MS8: 8 times with an interval of 4 days. After 2 and 6 weeks after the last injection, a histological examination of the lungs was performed; after 6 weeks: echocardiographic study (TTE), right ventricular catheterization (RV) with measurement of right ventricular systolic pressure (RVSP), treadmill test, assessment of serum endothelin1 levels by the immunoassay method.Results. During the experiments, the survival rate in the MS8 group was 50 %. In the other groups, there were no animal losses. According to the treadmill test 6 weeks after the modeling of PE, exercise tolerance was signifcantly reduced in the MC4 and MC8 groups compared with the control group. TTE data indicate a signifcant increase in the diameter of the pulmonary trunk and the right ventricular outflow tract in the MC8 compared with the control and AT. There were signifcant increase in RVSP and the level of endothelin1 compared with the control only in the MS8. After 6 weeks, the index of hypertrophy of vessel wall of the pulmonary artery in the MC4 and MC8 was signifcantly higher compared with the control and AT groups.Conclusion. Based on the use of MS, administered under the MS 8 protocol, a new representative model of CTEPH has been created, which can be used to test promising pharmacological substances.
The purpose of this article is to highlight some theoretical foundations for a connection between critical thinking and creativity as concepts to develop at school, to find the feasibility of use of ICT in such lessons, and to give examples of lessons conducted in such a logic. The competence approach, despite the ambiguous attitude towards it in secondary vocational education, has been re-examined by researchers in connection with a new wave of discussion on how to develop key competencies in secondary education. Critical thinking and creativity are seen as part of key competencies. The article describes in detail these constructs and correlates with well-known works of Russian and foreign practitioners and psychologists, such as L. Vygotsky, J. Piaget, and J. Dewey. The concepts overlap in many ways, which should be taken into account when evaluating innovation and designing educational experience of students. Despite the some differences, the existing modern didactic Russian and foreign approaches (such as problem-based learning, activity-based approach, student-centered learning, and others) meet the objectives and organization of a lesson, which foster critical thinking and creativity. Portable digital devices contribute to the development of greater student autonomy, which is one of the most important components of the development of key competencies. The final part of the article is structured through three theses on implementation of ICT in such lessons with examples of use of such practices by teachers during the project “Fostering creativity and critical thinking in education with the use of ICT” in 2018–2019. Examples allow us to determine how theoretical concepts, having many diachronic intersections, can be implemented in practice.
Introduction. Chronic thromboembolic pulmonary hypertension (CTEPH) is the most common complication of pulmonary thromboembolism (PE). Fibrous remodeling of the pulmonary circulation vessels against the background of CTEPH leads to an irreversible increase of the vessel wall stiffness and the ineffectiveness of CTEPH treatment. The involvement of Janus kinase (JAK) in the regulation of vascular wall and lung tissue inflammation and fibrosis allows for the possible effectiveness of JAK 1,2 inhibitors (iJAK) in the course of CTEPH. Purpose – to study the antifibrotic effect of iJAK for the prevention and treatment of CTEPH. Materials and methods. The study was conducted on male Wistar rats. Modeling of CTEPH was performed by sequential embolization of the vascular bed with partially biodegradable sodium alginate microspheres. 2 weeks after the last administration of the microspheres, low, medium and high doses of iJAK were initiated. To assess the effectiveness of the substance, the following tests were used: treadmill test, echocardiography, cardiac catheterization with right ventricular (RV) manometry, histological examination of the lungs. Results. Animals undergone vascular embolization demonstrated decreased exercise tolerance at all observation points compared to healthy animals. The placebo group, in contrast with the group getting treatment and iJAK, was found to have an increased mean RV pressure compared to healthy animals. There was an increase in mean RV pressure in the placebo group (15.5±7.7 mmHg) and in the low dose and iJAK group (13.4±6.4 mmHg) compared with healthy animals (9.4±2.2 mmHg). Vascular hypertrophy of the pulmonary artery branches was lower in group getting average dosages and iJAK compared with the placebo group (54.9±19.0 and 68.9±23.1 %, respectively). Thus, the suppression by iJAK of aseptic inflammation and following fibrosis leads to the decreasing of severity of pulmonary circulation remodeling in the experimental model of CTEPH. This approach can be used in the comprehensive bypass and prevention of CTEPH.
<p>This article examines the change in teachers' beliefs regarding new educational outcomes and new forms of using digital tools. For six months, 18 teachers developed and conducted lessons that form students' critical and creative thinking. At the same time, ICT tools were used not only by the teacher, but, most importantly, by students themselves. The intervention took place within the framework of the ‘action research’ approach, where the author acted as an organizer and a facilitator of the process. All teachers received preliminary training and were involved in the action research. As a result, it was revealed that the change of beliefs occurs during the transformation of practice, considering the fact that teachers were in exploratory, reflexive position regarding their own activities. That is, the condition for changing teachers' perceptions was a continuous personal experience of using, testing new tools in a professional context and reflecting on new practices.</p>
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