We report the clinical and pathological features of a cardiac fatality caused by granulocytic sarcoma in a young adult man with no evidence of leukemia involving bone marrow or peripheral blood. At autopsy, walls of the four cardiac chambers were massively infiltrated by tumor, resulting in a cardiac weight of almost three times normal. Routine cytochemical stains plus immunoperoxidase staining for OKM1 confirmed the diagnosis. Although subclinical cardiac infiltrates are commonly detected at autopsy in patients with acute nonlymphoblastic leukemia (ANLL), massive cardiac granulocytic sarcoma in the absence of bone marrow disease has not been previously described. Cytochemical and immunological methods of diagnosing granulocytic sarcoma in fixed tissues are reviewed.
Previous studies show the importance of iron-and arsenate-reducing bacteria in mobilizing arsenic in groundwater. Here the authors present experimental evidence of arsenic mobilization in connection with bacterially-mediated manganese reduction in groundwater affected by mining activities. Manganese-reducing Pseudomonas species were enriched, isolated and identified by 16S rDNA phylogeny from groundwater containing high co-dissolved arsenic (as As III ) and manganese. Enrichment cultures dissolved synthetic birnessite and haussmannite efficiently, but Mn reduction by isolates was greatly reduced at upper environmental levels of dissolved As III .Results suggest either a self-limiting release of arsenic coupled to bacterial manganese reduction, in the absence of other electron donors like sulfide, or increased arsenic resistance conferred to Mn-reducing bacteria in consortia.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.